Poly-Left-Lactic Acid tubular scaffolds via Diffusion Induced Phase Separation (DIPS): control of morphology

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14 Citazioni (Scopus)

Abstract

In this work, tubular poly-left-lactic acid scaffolds forvascular tissue engineering applications were producedby an innovative two-step method. The scaffoldswere obtained by performing a dip-coating around anylon fiber, followed by a diffusion induced phase separationprocess. Morphological analysis revealed thatthe internal lumen of the as-obtained scaffold is equalto the diameter of the fiber utilized; the internal surfaceis homogeneous with micropores 1–2 lm large. Moreover,a porous open structure was detected across thethickness of the walls of the scaffold. An accurateanalysis of the preparation process revealed that it ispossible to tune up the morphology of the scaffold(wall thickness, porosity, and average pore dimension),simply by varying some experimental parameters. Preliminaryin vitro cell culture tests were carried outinside the scaffold. The results showed that cells areable to grow within the internal surface of the scaffoldsand after 3 weeks they begin to form a ‘‘primordial’’vessel-like structure. Modeling predictions of the dipcoatingprocess display always an underestimate ofexperimental data (dependence of wall thickness uponextraction rate).
Lingua originaleEnglish
pagine (da-a)431-442
Numero di pagine12
RivistaPolymer Engineering and Science
Volume53
Stato di pubblicazionePublished - 2013

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.2500.2507???
  • ???subjectarea.asjc.2500.2505???

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