Pollen-induced allergic rhinitis in 1360 Italian children: Comorbidities and determinants of severity

Stefania La Grutta, Giuseppe Pingitore, Iolanda Chinellato, Mariangela Tosca, Arianna Dondi, Francesco Paravati, Laura Rinaldi, Francesco Macrì, Simona Sodano, Valerio Massaccesi, Giampaolo Ricci, Andrea Di Rienzo Businco, Annamaria Bianchi, Mario Plebani, Michele Miraglia Del Giudice, Iride Dello Iacono, Loredana Chini, Umberto Pelosi, Maria Francesca Patria, Elena VarinPaolo Meglio, Valentina Panetta, Nunzia Maiello, Viviana Moschese, Stefania La Grutta, Salvatore Tripodi, Diego Peroni, Sandra Lucarelli, Carlo Caffarelli, Tullio Frediani, Michele Miraglia Del Giudice, Antonio Carlucci, Paolo Maria Matricardi, Roberto Bernardini, Riccardo Asero, Mauro Calvani, Federica Bellini

    Risultato della ricerca: Articlepeer review

    47 Citazioni (Scopus)

    Abstract

    BACKGROUND:Pollen-induced allergic rhinoconjunctivitis (AR) is highly prevalent and rapidly evolving during childhood. General practitioners may not be fully aware of the nature and severity of symptoms experienced by patients and might underestimate the prevalence of moderate or severe disease. Thus, the relevance of early diagnosis and intervention may be overlooked.OBJECTIVES:To investigate the severity of pollen-induced AR and its determinants in Italian children referred to allergy specialists and who had never received specific immunotherapy (SIT).METHODS:Children (age 4-18 yr) affected by pollen-induced AR who had never undergone SIT were recruited between May 2009 and June 2011 in 16 pediatric outpatient clinics in 14 Italian cities. Recruited children's parents answered standardized questionnaires on atopic diseases (International Study of Allergy and Asthma in Childhood, Allergic Rhinitis and its Impact on Asthma, Global Initiative for Asthma). The children underwent skin-prick test (SPT) with several airborne allergens and six food allergens. Information on socio-demographic factors, parental history of allergic diseases, education, perinatal events, breastfeeding, nutrition and environmental exposure in early life was collected through an informatics platform shared by the whole network of clinical centers (AllergyCARD™).RESULTS:Among the 1360 recruited patients (68% males, age 10.5 ± 3.4 yr), 695 (51%) had moderate-to-severe AR, 533 (39%) asthma, and 325 (23.9%) oral allergy syndrome (OAS). Reported onset of pollen-induced AR was on average at 5.3 ± 2.8 yr, and its mean duration from onset was 5.2 ± 3.3 yr. Only 6.2% of the patients were pollen-monosensitized, and 84.9% were sensitized to ≥3 pollens. A longer AR duration was significantly associated with moderate-to-severe AR symptoms (p 0.004), asthma (p 0.030), and OAS comorbidities (p < 0.001).CONCLUSIONS:This nationwide study may raise awareness of the severity of pollen-induced AR among Italian children who have never received pollen SIT. The strong association between pollen-induced AR duration and several markers of disease severity needs replication in longitudinal studies, while suggesting that countrywide initiatives for earlier diagnosis and intervention should be planned.
    Lingua originaleEnglish
    pagine (da-a)742-751
    Numero di pagine10
    RivistaPediatric Allergy and Immunology
    Volume24
    Stato di pubblicazionePublished - 2013

    All Science Journal Classification (ASJC) codes

    • Pediatrics, Perinatology, and Child Health
    • Immunology and Allergy
    • Immunology

    Fingerprint Entra nei temi di ricerca di 'Pollen-induced allergic rhinitis in 1360 Italian children: Comorbidities and determinants of severity'. Insieme formano una fingerprint unica.

    Cita questo