Polimorfismo I/D del gene per l'enzima di conversione dell'angiotensina (ACE): gene della longevità o fattore di rischio nella patologia ipertensiva?

Antonietta Caruso, Luisa Agnello, Bruna Lo Sasso, Marcello Ciaccio, Chiara Bellia, Federica Bazza, Manuela Scorza, Angelo Zinnellu, Federica Zarrilli, Rossella Tomaiuolo, Luca Deiana, Ciriaco Carru

Risultato della ricerca: Article

Abstract

In recent decades, the increase in life expectancy stimulated the study of aging processes and the search forcandidate genes involved in longevity. The angiotensin converting enzyme (ACE), present in all endothelial cells, playsan essential role in maintaining the homeostasis of blood flow by regulating the production of the vasoconstrictorangiotensin II and inactivating the bradykinin. Some studies reported a possible association between the polymorphismI/D of ACE gene and either hypertension and longevity. The present study was aimed to confirm these data. We studiedtwo large cohorts of nonagenarians and centenarians. One was from Sardinia (200 subjects, 88 males, mean age: 96years) and their data were compared to a group of 222 subjects (106 males, mean age: 44 years) from the generalpopulation of the same geographic area. The latter group of longeve subjects (161 subjects, 71 males, mean age: 97years) was from Southern Italy. Furthermore, we studied 146 hypertensive patients (98 males, mean age: 51 years) and172 normotensive subjects (86 males, mean age: 33 years) from Southern Italy. The ACE I/D polymorphism was typedby polymerase chain reaction; the amplified 490 bp (allele I) and 190 bp (allele D) were visualized on 2% agarose gel.Hypertensive subjects had a significantly different distribution of ACE genotypes as compared to normotensive ones(P=0.001) and a higher frequency of the D/D genotype. Long-lived subjects from Sardinia showed a significantly differentdistribution of ACE genotypes as compared to subjects from the general population of the same geographic area (P<0.001), to long-lived subjects from Southern Italy (P <0.001), to hypertensive patients (P=0.011) and to normotensivesubjects from Southern Italy (P <0.001). Surprisingly, they had the highest frequency of the D/D genotype among thecompared groups. Our study indicates that: i) centenarians of different ethnic origin have a different genetic background,ii) there is a possible association between longevity and allelic variants of ACE, even if only in specific ethnic groups (i.e.,Sardinian) and iii) ACE polymorphisms are a predisposing factor to hypertension.
Lingua originaleItalian
pagine (da-a)461-464
Numero di pagine4
RivistaBiochimica Clinica
Volume37
Stato di pubblicazionePublished - 2013

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry
  • Medical Laboratory Technology
  • Biochemistry, medical

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