Pneumococcal Colonization in the FamilialContext and Implications for Anti-PneumococcalImmunization in Adults: Results fromthe BINOCOLO Project in Sicily

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Abstract

The spread of Streptococcus pneumoniae within families has been scarcely investigated sofar. This feasibility study aimed to estimate the prevalence of pneumococcal carriage in school-agedchildren and co-habiting relatives and to explore the potential link between the family environmentand the sharing of pneumococcal serotypes covered by the vaccine. Oropharyngeal samples of146 subjects belonging to 36 different family groups were molecularly tested for pneumococcaldetection and serotyping. The overall prevalence of pneumococcal carriage was 65.8% (n = 96/146),whereas it was higher among schoolchildren (77.8%, n = 28/36); subjects of seven years of age hadthe highest odds of being colonized (odds ratio, OR = 5.176; p = 0.145). Pneumococcal serotypesincluded in the 13-valent conjugate vaccine formulation were largely detected in the study populationand multiple serotypes colonization was considerable. Factors relating to a close proximity amongpeople at the family level were statistically associated with pneumococcal carriage (OR = 2.121;p = 0.049), as well as active smoking habit with a clear dose-response effect (ORs = 1.017–3.326).About half of family clusters evidenced similar patterns of carried pneumococcal serotypesand the odds of sustaining a high level of intrafamilial sharing increased with household size(ORs = 1.083–5.000). This study highlighted the potential role played by the family environment insustaining both the circulation and horizontal transmission of pneumococcus.
Lingua originaleEnglish
pagine (da-a)1-15
Numero di pagine15
RivistaInternational Journal of Molecular Sciences
Volume18
Stato di pubblicazionePublished - 2017

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carriages
Sicily
Conjugate Vaccines
Vaccines
vaccines
streptococcus
pneumonia
sustaining
habits
Streptococcus pneumoniae
proximity
formulations
Serotyping
dosage
Feasibility Studies
estimates
Habits
Smoking
Odds Ratio

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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title = "Pneumococcal Colonization in the FamilialContext and Implications for Anti-PneumococcalImmunization in Adults: Results fromthe BINOCOLO Project in Sicily",
abstract = "The spread of Streptococcus pneumoniae within families has been scarcely investigated sofar. This feasibility study aimed to estimate the prevalence of pneumococcal carriage in school-agedchildren and co-habiting relatives and to explore the potential link between the family environmentand the sharing of pneumococcal serotypes covered by the vaccine. Oropharyngeal samples of146 subjects belonging to 36 different family groups were molecularly tested for pneumococcaldetection and serotyping. The overall prevalence of pneumococcal carriage was 65.8{\%} (n = 96/146),whereas it was higher among schoolchildren (77.8{\%}, n = 28/36); subjects of seven years of age hadthe highest odds of being colonized (odds ratio, OR = 5.176; p = 0.145). Pneumococcal serotypesincluded in the 13-valent conjugate vaccine formulation were largely detected in the study populationand multiple serotypes colonization was considerable. Factors relating to a close proximity amongpeople at the family level were statistically associated with pneumococcal carriage (OR = 2.121;p = 0.049), as well as active smoking habit with a clear dose-response effect (ORs = 1.017–3.326).About half of family clusters evidenced similar patterns of carried pneumococcal serotypesand the odds of sustaining a high level of intrafamilial sharing increased with household size(ORs = 1.083–5.000). This study highlighted the potential role played by the family environment insustaining both the circulation and horizontal transmission of pneumococcus.",
author = "Emanuele Amodio and Francesco Vitale and Fabio Tramuto and Claudio Costantino and Giuseppe Calamusa and Vincenzo Restivo",
year = "2017",
language = "English",
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journal = "International Journal of Molecular Sciences",
issn = "1661-6596",
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TY - JOUR

T1 - Pneumococcal Colonization in the FamilialContext and Implications for Anti-PneumococcalImmunization in Adults: Results fromthe BINOCOLO Project in Sicily

AU - Amodio, Emanuele

AU - Vitale, Francesco

AU - Tramuto, Fabio

AU - Costantino, Claudio

AU - Calamusa, Giuseppe

AU - Restivo, Vincenzo

PY - 2017

Y1 - 2017

N2 - The spread of Streptococcus pneumoniae within families has been scarcely investigated sofar. This feasibility study aimed to estimate the prevalence of pneumococcal carriage in school-agedchildren and co-habiting relatives and to explore the potential link between the family environmentand the sharing of pneumococcal serotypes covered by the vaccine. Oropharyngeal samples of146 subjects belonging to 36 different family groups were molecularly tested for pneumococcaldetection and serotyping. The overall prevalence of pneumococcal carriage was 65.8% (n = 96/146),whereas it was higher among schoolchildren (77.8%, n = 28/36); subjects of seven years of age hadthe highest odds of being colonized (odds ratio, OR = 5.176; p = 0.145). Pneumococcal serotypesincluded in the 13-valent conjugate vaccine formulation were largely detected in the study populationand multiple serotypes colonization was considerable. Factors relating to a close proximity amongpeople at the family level were statistically associated with pneumococcal carriage (OR = 2.121;p = 0.049), as well as active smoking habit with a clear dose-response effect (ORs = 1.017–3.326).About half of family clusters evidenced similar patterns of carried pneumococcal serotypesand the odds of sustaining a high level of intrafamilial sharing increased with household size(ORs = 1.083–5.000). This study highlighted the potential role played by the family environment insustaining both the circulation and horizontal transmission of pneumococcus.

AB - The spread of Streptococcus pneumoniae within families has been scarcely investigated sofar. This feasibility study aimed to estimate the prevalence of pneumococcal carriage in school-agedchildren and co-habiting relatives and to explore the potential link between the family environmentand the sharing of pneumococcal serotypes covered by the vaccine. Oropharyngeal samples of146 subjects belonging to 36 different family groups were molecularly tested for pneumococcaldetection and serotyping. The overall prevalence of pneumococcal carriage was 65.8% (n = 96/146),whereas it was higher among schoolchildren (77.8%, n = 28/36); subjects of seven years of age hadthe highest odds of being colonized (odds ratio, OR = 5.176; p = 0.145). Pneumococcal serotypesincluded in the 13-valent conjugate vaccine formulation were largely detected in the study populationand multiple serotypes colonization was considerable. Factors relating to a close proximity amongpeople at the family level were statistically associated with pneumococcal carriage (OR = 2.121;p = 0.049), as well as active smoking habit with a clear dose-response effect (ORs = 1.017–3.326).About half of family clusters evidenced similar patterns of carried pneumococcal serotypesand the odds of sustaining a high level of intrafamilial sharing increased with household size(ORs = 1.083–5.000). This study highlighted the potential role played by the family environment insustaining both the circulation and horizontal transmission of pneumococcus.

UR - http://hdl.handle.net/10447/221226

UR - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5297739/pdf/ijms-18-00105.pdf

M3 - Article

VL - 18

SP - 1

EP - 15

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1661-6596

ER -