Phytochemical-rich extracts of Helianthemumlippii possess antimicrobial, anticancer, and antibiofilmactivities

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Helianthemum lippii is a perennial shrubby plant growing in the sandy environments of Italy,Mediterranean countries of North Africa and Middle East. H. lippii is used in traditionalmedicine but there are very few reports referring to the phytochemical characterization, theethnopharmacology, and the biological activity of H. lippii. The goal of this study was todetermine the phytochemical composition of different H. lippii extracts, cold (CME) and hot(HME) methanol, cold (CPEE) and hot (HPEE) petroleum ether, as well as to evaluate theiranticancer and antimicrobial activities and biofilm formation reduction. Fifty-foursphytocompounds have been determined by HPLC-UV-ESI-QTOF-MS analysis. All the fourextracts reduced the viability of human MDA-MB231 and HCT116 cells, being cold and hotmethanol extracts the most effective. The antimicrobial activity against S. aureus, P.aeruginosa, E. faecalis, E. coli, C. albicans was also evaluated. Data showed the greatersusceptibility of S. aureus to hot methanolic extract. Concerning antifungal activity, C.albicans resulted more susceptible to petroleum ether. Moreover, some of the samplesexhibited a good antibiofilm activity both on immature and on mature biofilms. The fourextracts showed interesting antimicrobial and cytotoxic activities and can be considered goodcandidates for new therapeutic applications
Lingua originaleEnglish
pagine (da-a)1-31
Numero di pagine31
RivistaPlant Biosystems
Stato di pubblicazionePublished - 2022

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.1100.1110???


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