TY - JOUR
T1 - Phytochemical-rich extracts of Helianthemumlippii possess antimicrobial, anticancer, and antibiofilmactivities
AU - Catania, Valentina
AU - D'Anneo, Antonella
AU - Venturella, Fabio
AU - Raffa, Demetrio
AU - Schillaci, Domenico
AU - Venturella, Giuseppe
AU - Plescia, Fabiana
AU - Palumbo Piccionello, Antonio
AU - Lauricella, Marianna
AU - Gargano, Maria Letizia
AU - Venturella, Fabio
AU - Polito, Giulia
PY - 2022
Y1 - 2022
N2 - Helianthemum lippii is a perennial shrubby plant growing in the sandy environments of Italy,Mediterranean countries of North Africa and Middle East. H. lippii is used in traditionalmedicine but there are very few reports referring to the phytochemical characterization, theethnopharmacology, and the biological activity of H. lippii. The goal of this study was todetermine the phytochemical composition of different H. lippii extracts, cold (CME) and hot(HME) methanol, cold (CPEE) and hot (HPEE) petroleum ether, as well as to evaluate theiranticancer and antimicrobial activities and biofilm formation reduction. Fifty-foursphytocompounds have been determined by HPLC-UV-ESI-QTOF-MS analysis. All the fourextracts reduced the viability of human MDA-MB231 and HCT116 cells, being cold and hotmethanol extracts the most effective. The antimicrobial activity against S. aureus, P.aeruginosa, E. faecalis, E. coli, C. albicans was also evaluated. Data showed the greatersusceptibility of S. aureus to hot methanolic extract. Concerning antifungal activity, C.albicans resulted more susceptible to petroleum ether. Moreover, some of the samplesexhibited a good antibiofilm activity both on immature and on mature biofilms. The fourextracts showed interesting antimicrobial and cytotoxic activities and can be considered goodcandidates for new therapeutic applications
AB - Helianthemum lippii is a perennial shrubby plant growing in the sandy environments of Italy,Mediterranean countries of North Africa and Middle East. H. lippii is used in traditionalmedicine but there are very few reports referring to the phytochemical characterization, theethnopharmacology, and the biological activity of H. lippii. The goal of this study was todetermine the phytochemical composition of different H. lippii extracts, cold (CME) and hot(HME) methanol, cold (CPEE) and hot (HPEE) petroleum ether, as well as to evaluate theiranticancer and antimicrobial activities and biofilm formation reduction. Fifty-foursphytocompounds have been determined by HPLC-UV-ESI-QTOF-MS analysis. All the fourextracts reduced the viability of human MDA-MB231 and HCT116 cells, being cold and hotmethanol extracts the most effective. The antimicrobial activity against S. aureus, P.aeruginosa, E. faecalis, E. coli, C. albicans was also evaluated. Data showed the greatersusceptibility of S. aureus to hot methanolic extract. Concerning antifungal activity, C.albicans resulted more susceptible to petroleum ether. Moreover, some of the samplesexhibited a good antibiofilm activity both on immature and on mature biofilms. The fourextracts showed interesting antimicrobial and cytotoxic activities and can be considered goodcandidates for new therapeutic applications
UR - http://hdl.handle.net/10447/540447
M3 - Article
SN - 1126-3504
SP - 1
EP - 31
JO - Plant Biosystems
JF - Plant Biosystems
ER -