Phytochemical and pharmacological studies on the acetonic extract of Marrubium globosum ssp. libanoticum

Maurizio Bruno, Armando Grassia, Francesca Borrelli, Daniela Rigano, Felice Senatore, Raffaele Capasso, Nelly Apostolides Arnold, Gabriella Aviello

Risultato della ricerca: Articlepeer review

24 Citazioni (Scopus)

Abstract

A new natural labdane diterpene, marrulibanoside, was isolated from the acetonic extract of aerial parts of M. globosum Montbr. et Auch. ex Benth. ssp. libanoticum Boiss. (Lamiaceae). Its structure was determined by spectroscopic methods such as 1D and 2D NMR and mass spectrometry. Pharmacological studies have shown that the extract of M. globosum exerts anti-inflammatory effects in the rat paw oedema induced by carrageenin resulting in reduced paw swelling. This activity, which seems due to marrulibanoside, is a consequence of iNOS and COX-2 activities inhibition.
Lingua originaleEnglish
pagine (da-a)575-578
Numero di pagine4
RivistaPlanta Medica
Volume72
Stato di pubblicazionePublished - 2006

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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