Phytochemical and anti‑staphylococcal biofilm assessment of Dracaena draco L. Spp. draco resin

Background: Dracaena draco L. ssp. draco is known as the “dragon’s blood tree” and it isendemic from the Canary Islands and Morocco. Objective: Carry out phytochemical investigationof acetonic extracts of red resin obtained from the trunk of D. draco, to obtain to the isolation ofthe most abundant resin constituents, belonging to the class of flavonoids: flavans, along withhomoisoflavans and homoisoflavanones. Materials and Methods: The structures of the isolatedcompounds were established by Nuclear Magnetic Resonance (NMR) and mass spectrometry dataand comparison with literature data. The acetonic extract was evaluated for its anti‑staphylococcalproperties against two reference strains. Results: The acetonic extracts resulted inactive at themaximum tested concentration of 1000 μg/ml against free living forms of tested staphylococci, butthey showed a very interesting activity in the prevention of a biofilm formation at a concentrationequal to 200 μg/ml against S. aureus ATCC 25923.