Physicochemical Properties of A New PEGylated Polybenzofulvene Brush for Drug Encapsulation

Mariano Licciardi, Antonella Caterina Boccia, Marco Paolino, Daniele Piovani, Mariangela Gentile, Vincenzo Razzano, Annalisa Reale, Daniele Piovani, Daniele Piovani, Eugenio Paccagnini, Laura Salvini, Filippo Samperi, Raniero Mendichi, Chiara Botta, Alessandro Donati, Andrea Cappelli, Germano Giuliani, Gianluca Giorgi

Risultato della ricerca: Articlepeer review

2 Citazioni (Scopus)

Abstract

A new polymer brush was synthesized by spontaneous polymerization of benzofulvene macromonomer 6-MOEG-9-T-BF3k bearing a nona(ethylene glycol) side chain linked to the 3-phenylindene scaffold by means of a triazole heterocycle. The polymer structure was studied by SEC-MALS, NMR spectroscopy, and MALDI-TOF MS techniques, and the results supported the role of oligomeric initiatory species in the spontaneous polymerization of polybenzofulvene derivatives. The aggregation features of high molecular weight poly-6-MOEG-9-T-BF3k-FE were investigated by pyrene fluorescence analysis, dynamic light scattering studies, and transmission electron microscopy, which suggested a tendency towards the formation of spherical objects showing dimensions in the range of 20–200 nm. Moreover, poly-6-MOEG-9-T-BF3k-FE showed an interesting cytocompatibility in the whole concentration range tested that, besides its aggregation features, makes this polybenzofulvene brush a good polymer candidate for nanoencapsulation and delivery of drug molecules. Finally, the photo-physical features of poly-6-MOEG-9-T-BF3k-FE could allow the biodistribution of the resulting drug delivery systems to be monitored by fluorescence microscopy techniques.
Lingua originaleEnglish
Numero di pagine22
RivistaPharmaceutics
Volume11
Stato di pubblicazionePublished - 2019

All Science Journal Classification (ASJC) codes

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