Photosynthesized silver–polyaminocyclodextrin nanocomposites as promising antibacterial agents with improved activity

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Abstract

Ag nanocomposites were prepared by photoreduction of ammoniacal silver acetate in the presence of poly-{6-[3-(2-(3-aminopropylamino)ethylamino)propylamino]}-(6-deoxy)-b-CD (amCD). The obtained systems were characterized by means of various complementary techniques (UV-vis, FT-IR, TEM, SAED). In particular, FT-IR spectroscopy evidenced a partial oxidative degradation of the polyamine branches of the capping auxiliary, due to the fact that these groups function as a sacrificial reducing agent in the photoinduced formation of the Ag metal core. TEM and SAED micrographs showed that the Ag cores possess a relatively low polydispersity and a significantly crystalline character. The Ag–amCD systems were assayed for antibacterial activity, using Escherichia coli and Kocuria rhizophila as Gram-negative and Gram-positive tester strains respectively. In addition, the systems function as supramolecular drug carriers, able to bind the b-lactam antibiotic ampicillin, as demonstrated by polarimetric measurements. Antimicrobial assays revealed MIC90 values against E. coli and K. rhizophila as large as a 5 and 1 mg mL1 respectively. Moreover, the interaction of the Ag–amCD with ampicillin resulted in a synergistic improvement of the antibacterial activity. This study provides insights on the attractive possibility to use a photochemical methodology to produce bioactive supramolecular systems to be employed aspowerful and tunable antimicrobial agents.
Lingua originaleEnglish
pagine (da-a)40090-40099
Numero di pagine10
RivistaRSC Advances
Volume6
Stato di pubblicazionePublished - 2016

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Bactericides
Ampicillin
Escherichia coli
Nanocomposites
Anti-Bacterial Agents
Transmission electron microscopy
Antimicrobial agents
Lactams
Drug Carriers
Reducing Agents
Polyamines
Polydispersity
Reducing agents
Antibiotics
Anti-Infective Agents
Infrared spectroscopy
Assays
Silver
Metals
Crystalline materials

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)

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title = "Photosynthesized silver–polyaminocyclodextrin nanocomposites as promising antibacterial agents with improved activity",
abstract = "Ag nanocomposites were prepared by photoreduction of ammoniacal silver acetate in the presence of poly-{6-[3-(2-(3-aminopropylamino)ethylamino)propylamino]}-(6-deoxy)-b-CD (amCD). The obtained systems were characterized by means of various complementary techniques (UV-vis, FT-IR, TEM, SAED). In particular, FT-IR spectroscopy evidenced a partial oxidative degradation of the polyamine branches of the capping auxiliary, due to the fact that these groups function as a sacrificial reducing agent in the photoinduced formation of the Ag metal core. TEM and SAED micrographs showed that the Ag cores possess a relatively low polydispersity and a significantly crystalline character. The Ag–amCD systems were assayed for antibacterial activity, using Escherichia coli and Kocuria rhizophila as Gram-negative and Gram-positive tester strains respectively. In addition, the systems function as supramolecular drug carriers, able to bind the b-lactam antibiotic ampicillin, as demonstrated by polarimetric measurements. Antimicrobial assays revealed MIC90 values against E. coli and K. rhizophila as large as a 5 and 1 mg mL1 respectively. Moreover, the interaction of the Ag–amCD with ampicillin resulted in a synergistic improvement of the antibacterial activity. This study provides insights on the attractive possibility to use a photochemical methodology to produce bioactive supramolecular systems to be employed aspowerful and tunable antimicrobial agents.",
author = "Giuseppe Gallo and Renato Noto and {Lo Meo}, {Paolo Maria Giuseppe} and Marco Russo and Alberto Sutera and {Chillura Martino}, {Delia Francesca}",
year = "2016",
language = "English",
volume = "6",
pages = "40090--40099",
journal = "RSC Advances",
issn = "2046-2069",
publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - Photosynthesized silver–polyaminocyclodextrin nanocomposites as promising antibacterial agents with improved activity

AU - Gallo, Giuseppe

AU - Noto, Renato

AU - Lo Meo, Paolo Maria Giuseppe

AU - Russo, Marco

AU - Sutera, Alberto

AU - Chillura Martino, Delia Francesca

PY - 2016

Y1 - 2016

N2 - Ag nanocomposites were prepared by photoreduction of ammoniacal silver acetate in the presence of poly-{6-[3-(2-(3-aminopropylamino)ethylamino)propylamino]}-(6-deoxy)-b-CD (amCD). The obtained systems were characterized by means of various complementary techniques (UV-vis, FT-IR, TEM, SAED). In particular, FT-IR spectroscopy evidenced a partial oxidative degradation of the polyamine branches of the capping auxiliary, due to the fact that these groups function as a sacrificial reducing agent in the photoinduced formation of the Ag metal core. TEM and SAED micrographs showed that the Ag cores possess a relatively low polydispersity and a significantly crystalline character. The Ag–amCD systems were assayed for antibacterial activity, using Escherichia coli and Kocuria rhizophila as Gram-negative and Gram-positive tester strains respectively. In addition, the systems function as supramolecular drug carriers, able to bind the b-lactam antibiotic ampicillin, as demonstrated by polarimetric measurements. Antimicrobial assays revealed MIC90 values against E. coli and K. rhizophila as large as a 5 and 1 mg mL1 respectively. Moreover, the interaction of the Ag–amCD with ampicillin resulted in a synergistic improvement of the antibacterial activity. This study provides insights on the attractive possibility to use a photochemical methodology to produce bioactive supramolecular systems to be employed aspowerful and tunable antimicrobial agents.

AB - Ag nanocomposites were prepared by photoreduction of ammoniacal silver acetate in the presence of poly-{6-[3-(2-(3-aminopropylamino)ethylamino)propylamino]}-(6-deoxy)-b-CD (amCD). The obtained systems were characterized by means of various complementary techniques (UV-vis, FT-IR, TEM, SAED). In particular, FT-IR spectroscopy evidenced a partial oxidative degradation of the polyamine branches of the capping auxiliary, due to the fact that these groups function as a sacrificial reducing agent in the photoinduced formation of the Ag metal core. TEM and SAED micrographs showed that the Ag cores possess a relatively low polydispersity and a significantly crystalline character. The Ag–amCD systems were assayed for antibacterial activity, using Escherichia coli and Kocuria rhizophila as Gram-negative and Gram-positive tester strains respectively. In addition, the systems function as supramolecular drug carriers, able to bind the b-lactam antibiotic ampicillin, as demonstrated by polarimetric measurements. Antimicrobial assays revealed MIC90 values against E. coli and K. rhizophila as large as a 5 and 1 mg mL1 respectively. Moreover, the interaction of the Ag–amCD with ampicillin resulted in a synergistic improvement of the antibacterial activity. This study provides insights on the attractive possibility to use a photochemical methodology to produce bioactive supramolecular systems to be employed aspowerful and tunable antimicrobial agents.

UR - http://hdl.handle.net/10447/177263

M3 - Article

VL - 6

SP - 40090

EP - 40099

JO - RSC Advances

JF - RSC Advances

SN - 2046-2069

ER -