Photoluminescent decoration of iron oxide magnetic nanoparticles for dual-imaging applications

Antonio Palumbo Piccionello, Andrea Pace, Luca Menichetti, Erica Locatelli, Alessandra Flori, Paolo Armanetti, Mirko Maturi, Ilaria Monaco

Risultato della ricerca: Article

Abstract

A selective functionalization of dopamine amino group with the photoluminescent 7-nitroben-zofurazan was achieved through a one-pot protection-functionalization-deprotection sequence. The resulting fluorescent catecholic ligand was used as a capping agent for iron oxide nanoparticles thus obtaining photoluminescent magnetic nanoparticles (PL-MNPs). The PL-MNPs were then embedded into PLGA-b-PEG polymeric nanocarriers which quenched the emission of the capping agent. Full recovery of fluorescence was observed after disassembling the polymeric layer of the nanoparticle, thus supporting the use of PL-MNPs as a multifunctional system for targeted drug delivery.
Lingua originaleEnglish
Numero di pagine7
RivistaJournal of Nanoparticle Research
Volume20
Stato di pubblicazionePublished - 2018

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All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Atomic and Molecular Physics, and Optics
  • Chemistry(all)
  • Modelling and Simulation
  • Materials Science(all)
  • Condensed Matter Physics

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