Photodynamic therapy with verteporfin for subfoveal choroidal neovascularization secondary to pathologic myopia: long-term study.

Domenica Matranga, Maria Vadala', Alfredo Pece, Vincenzo Isola

Risultato della ricerca: Article

37 Citazioni (Scopus)


Purpose: To assess the safety and effectiveness of photodynamic therapy (PDT) withverteporfin for subfoveal choroidal neovascularization (CNV) secondary to pathologicmyopia (PM).Methods: Sixty-two patients (62 eyes) with PM underwent PDT according to theguidelines of the Verteporfin in Photodynamic Therapy Study. Clinical evaluations performedat all study visits included measurement of best-corrected Snellen visual acuity,slit-lamp biomicroscopy, and fundus fluorescein angiography. Patients were followed up at1 month and 3 months after treatment and thereafter at 3-month intervals.Results: The final visual acuity of the study patients, after a median follow-up of 31months, improved by 1 Snellen lines in 8 patients (13%), deteriorated in 20 (32%), andremained stable in 34 (55%). The baseline visual acuity was similar in the various studygroups. The final mean visual acuity in group A (55 years of age or younger) was 20/80 andsignificantly (P 0.006) better than that (20/138) in group B (older than 55 years of age).The mean final visual acuity in eyes with higher refractive error at baseline (greater than 17 diopters) was significantly better (P 0.014) than that in eyes with lower refractiveerror ( 6 to 10 diopters). CNV size did not affect visual outcomes.Conclusion: PDT preserves vision in patients with CNV associated with PM. Youngerpatients and eyes with higher refractive error appear more likely to benefit from PDT withverteporfin.
Lingua originaleEnglish
pagine (da-a)746-751
Numero di pagine6
Stato di pubblicazionePublished - 2006


All Science Journal Classification (ASJC) codes

  • Ophthalmology

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