PHOTOCROSSLINKING OF DEXTRAN AND POLYASPARTAMIDE DERIVATIVES: A COMBINATION SUITABLE FOR COLON- SPECIFIC DRUG DELIVERY.

Gaetano Giammona, Fabio Salvatore Palumbo, Giovanna Pitarresi, Patrizia Paolicelli, Maria Antonietta Casadei, Delia Mandracchia

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49 Citazioni (Scopus)

Abstract

The aim of this study was to prepare and characterize novel hydrogels with polysaccharide–polyaminoacid structure, able to undergo anenzymatic hydrolysis in the colon and potentially useful for treating inflammatory bowel diseases (IBD). Starting materials were methacrylateddextran (DEX-MA) and methacrylated α,β-poly(N-2-hydroxyethyl)-DL-aspartamide (PHM). These polymers were photocrosslinked by exposureof their aqueous solutions at 313 nm without photoinitiators. Different samples, shaped as microparticles, were obtained as a function of polymerconcentration and irradiation time. FT-IR analysis confirmed the occurrence of a co-crosslinking between DEX-MA and PHM in all experimentalconditions. Size analysis evidenced a narrow particle distribution and swelling studies, performed in twice-distilled water and simulatedgastrointestinal fluids, showed a good affinity of these hydrogels towards the aqueous medium. DEX-MA/PHM based hydrogels undergo anegligible chemical hydrolysis, whereas they are partially degraded by dextranase. In vitro biological assays showed cell compatibility of thesesamples. Beclomethasone dipropionate (BDP), a drug recently proposed for the treatment of IBD was entrapped into a DEX-MA/PHM basedhydrogel and its release was evaluated in the absence or in the presence of dextranase. Obtained release profiles suggest the potential use of BDPloaded DEX-MA/PHM based hydrogels for the treatment of IBD.
Lingua originaleEnglish
pagine (da-a)328-338
Numero di pagine11
RivistaJournal of Controlled Release
Volume119 (3)
Stato di pubblicazionePublished - 2007

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

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