Photo-inhibition of Aβ fibrillation mediated by a newly designed fluorinated oxadiazole

Claudia Marino, Silvestre Buscemi, Antonio Palumbo Piccionello, Ortore, Pasquale Picone, Claudia Marino, San Biagio, Vilasi, Maria Rosalia Mangione, Bulone, Buscemi, Marta Di Carlo, Antonio Palumbo Piccionello, Maria Rosalia Mangione, Pier Luigi San Biagio

Risultato della ricerca: Articlepeer review

19 Citazioni (Scopus)

Abstract

Uncontrolled aggregation of amyloid beta peptide (Aβ) is the main cause of Alzheimer's disease. Therapeutic approaches to intervention in amyloid diseases include the use of small molecules able to stabilize the soluble Aβ conformation, or to redirect the amyloidogenic pathway towards non-toxic and non-fibrillar states. Fluorometric measurements revealed that 3-(4′-trifluoromethylphenyl)-5-(4′-methoxyphenyl)-1,2,4-oxadiazole, when irradiated, is able to interact with the monomeric Aβ peptide readdressing the aggregation pathway toward the formation of amorphous aggregates as evidenced by CD, AFM, and SAXS measurements. We hypothesize that this compound, under radiation, forms a reactive intermediate that sticks on the Aβ peptide by interfering with its fibrillation process. Cytotoxicity assays performed on LAN5 neuroblastoma cells suggest that the presence of oxadiazole reduces the toxicity of Aβ. This finding might be the start of innovative therapies against Alzheimer's disease.
Lingua originaleEnglish
pagine (da-a)16540-16548
Numero di pagine9
RivistaRSC Advances
Volume5
Stato di pubblicazionePublished - 2015

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)

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