Phenol compounds as new materials for Electron Spin Resonance (ESR) dosimetry in clinical photon and electron beams

Risultato della ricerca: Otherpeer review

Abstract

In the last decades several research laboratories have shown an increasing interest aimed at extending the applicability of ElectronSpin Resonance (ESR) dosimetry to radiotherapy with different types of radiation beams. ESR is a spectroscopic method forinvestigating the structure and dynamics of such paramagnetic species. Free radicals are known to be produced when a compoundis irradiated with ionizing radiations. The concentration of radiation-induced free radicals is proportional to the energy releasedinside in the medium and this allows for dosimetric measurements through ESR technique which able to quantitatively determinethe radical concentration.The use of alanine as a dosimetric material gave the possibility to apply ESR spectroscopy for high-dosestandardization and dose control in radiation processing. The ESR dosimetric method has many advantages such as simple andrapid dose evaluation, the readout procedure is non-destructive, linear response of many organic and inorganic compounds. ESRdetectors show a behavior that suggest possible applications for various kinds of beams used for radiation therapy. Nowadays, themost widely used organic compound as a dosimeter is the alanine. However, many researches are in progress with the aim atimproving sensitivity of ESR dosimetry for doses much smaller than 1 Gy. More sensitive materials than alanine are needed to makethe ESR dosimeter competitive with other dosimetry systems.Our research group has started an investigation of the ESR response of some phenols compounds for possible ESR dosimetricapplications suitable features, such as high efficiency of radiation-matter energy transfer and radical stability at room temperature.Phenols are compounds possessing a benzene ring attached to a OH group. After irradiation the final product is a stable phenoxyradical. The stability of such radical can be improved by adding other alkyl chains which can be attached to the benzene ring. Inparticular, the phenol octadecyl-3-(3,5-di-tert.butyl-4-hydroxyphenyl)-propionate gave interesting results. Moreover, its highmolecular weight, the low volatility and the compatibility with the dosimeter binding material (wax) are advantages with respect tolower molecular weight phenols.In this work we report the ESR investigation of phenols exposed to clinical photon and electron beams. The dosimetric features ofthese ESR dosimeters (dependence on microwave power and modulation amplitude, their response after gamma and electronirradiations, dependence on beam type and energy, the detection limits for both beam typologies, signal stability after irradiation)were investigated and the results are reported.
Lingua originaleEnglish
Numero di pagine1
Stato di pubblicazionePublished - 2015

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