Pharmacological therapy of non-alcoholic fatty liver disease: What drugs are available now and future perspectives

Federica Spatola, Grazia Pennisi, Salvatore Petta, Ciro Celsa, Salvatore Petta, Marcello Dallio, Ciro Celsa, Grazia Pennisi, Federica Spatola, Alessandro Federico

Risultato della ricerca: Article

Abstract

The non-alcoholic fatty liver disease (NAFLD) is rapidly becoming the most common cause of chronic liver disease as well as the first cause of liver transplantation. NAFLD is commonly associated with metabolic syndrome (MetS), and this is the most important reason why it is extremely difficult to treat this disease bearing in mind the enormous amount of interrelationships between the liver and other systems in maintaining the metabolic health. The treatment of NAFLD is a key point to prevent NASH progression to advanced fibrosis, to prevent cirrhosis and to prevent the development of its hepatic complications (such as liver decompensation and HCC) and even extrahepatic one. A part of the well-known healthy effect of diet and physical exercise in this setting it is important to design the correct pharmaceutical strategy in order to antagonize the progression of the disease. In this regard, the current review has the scope to give a panoramic view on the possible pharmacological treatment strategy in NAFLD patients.
Lingua originaleEnglish
pagine (da-a)4334-
Numero di pagine26
RivistaInternational Journal of Environmental Research and Public Health
Volume16
Stato di pubblicazionePublished - 2019

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All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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