Pharmacological stress, rest perfusion and delayed enhancement cardiac magnetic resonance identifies very early cardiac involvement in systemic sclerosis patients of recent onset

Francesco Ciccia, Giuliana Guggino, Giovanni Triolo, Vasiliki Liakouli, Francesco Carubbi, Paola Di Benedetto, Piero Ruscitti, Alessandra Di Sibio, Antonio Gennarelli, Onorina Berardicurti, Ganna Radchenko, Alessandra Splendiani, Carlo Masciocchi, Ernesto Di Cesare, Roberto Giacomelli, Paola Cipriani

Risultato della ricerca: Article

3 Citazioni (Scopus)

Abstract

Objective: To evaluate occult cardiac involvement in asymptomatic systemic sclerosis (SSc) patients by pharmacological stress, rest perfusion and delayed enhancement cardiac magnetic resonance (CMR), for a very early identification of patients at higher risk of cardiac-related mortality. Methods: Sixteen consecutive patients with definite SSc, fulfilling the American College of Rheumatology/European League Against Rheumatism 2013 classification criteria in less than 1 year from the onset of Raynaud's phenomenon, underwent pharmacological stress, rest perfusion and delayed enhancement CMR. At enrollment, no patient showed signs and/or symptoms suggestive for cardiac involvement. No patient showed traditional cardiovascular risk factors. Both the 12-lead electrocardiogram examination and echocardiographic evaluation did not show any alterations in our cohort. Results: Stress perfusion defects of left ventricle were detected in six out of 16 (37.5%) patients and these defects did not match with the coronary flow distribution. The results showed the presence of two different patterns of stress perfusion defects: sub-endocardial and/or a midmyocardial. The presence of stress perfusion defects did not correlate with any clinical feature of enrolled patients. Conclusion: Myocardial stress perfusion defects may be detected early by pharmacological stress perfusion CMR, a reliable and sensitive technique for the noninvasive evaluation of SSc heart disease, in patients with SSc of recent onset. These defects seem to be independent from traditional risk factors and associated comorbidities, suggesting they are a specific hallmark of the disease.
Lingua originaleEnglish
pagine (da-a)1247-1260
Numero di pagine14
RivistaInternational Journal of Rheumatic Diseases
Volume20
Stato di pubblicazionePublished - 2017

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All Science Journal Classification (ASJC) codes

  • Rheumatology

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Ciccia, F., Guggino, G., Triolo, G., Liakouli, V., Carubbi, F., Di Benedetto, P., Ruscitti, P., Di Sibio, A., Gennarelli, A., Berardicurti, O., Radchenko, G., Splendiani, A., Masciocchi, C., Di Cesare, E., Giacomelli, R., & Cipriani, P. (2017). Pharmacological stress, rest perfusion and delayed enhancement cardiac magnetic resonance identifies very early cardiac involvement in systemic sclerosis patients of recent onset. International Journal of Rheumatic Diseases, 20, 1247-1260.