Pharmacological manipulation of serotonin receptors during brain embryogenesis favours stress resiliency in female rats

Anna Brancato, Emanuele Cannizzaro, Marco Giammanco, Danila Di Majo, Angela Cavallaro, Gianluca Lavanco

Risultato della ricerca: Articlepeer review

Abstract

Manipulations of the serotonin transmission during early development induce long-lasting changes in the serotonergic circuitry throughout the brain. However, little is known on the developmental consequences in the female progeny. Therefore, this study aimed at exploring the behavioural effects of pre- and postnatal stimulation of the serotonergic system by 5-methoxytryptamine in adolescent female rats on behavioural reactivity and anxiety- like phenotype. Our results show that perinatal 5- methoxythyptamine decreased total distance travelled and rearing frequency in the novel enviroment, and increased the preference for the centre of the arena in the open field test. Moreover, perinatal 5-methoxytryptamine increased the percentages of entries and time spent on the open arms of the elevated plus maze, with respect to perinatally vehicle-exposed rats. Thus, perinatal stimulation of serotonin receptors does not impair the functional response to the emotional challenges in female rats, favouring the occurrence of a stress-resilient phenotype.
Lingua originaleEnglish
pagine (da-a)116-119
Numero di pagine4
RivistaJOURNAL OF BIOLOGICAL RESEARCH
Volume90
Stato di pubblicazionePublished - 2017

All Science Journal Classification (ASJC) codes

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  • Plant Science
  • Biochemistry, medical

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