Pharmacogenomics in colorectal carcinomas: Future perspectives in personalized therapy

Patrizia Cammareri, Antonio Russo, Viviana Bazan, Gaetana Di Fede, Valentina Agnese, Antonio Russo, Marcella Macaluso, Sandra Cascio, Sandra Cascio

Risultato della ricerca: Articlepeer review

15 Citazioni (Scopus)


The recent introduction of new drugs such as capecitabine, irinotecan, and oxaliplatinum has greatly improved the clinical outcome of patients with advanced/metastatic colorectal cancer. Nevertheless, some patients may suffer from the adverse drug reactions which will probably be the main cause of chemotherapy failure. The goal of pharmacogenomics is to find correlations between therapeutic responses to drugs and the genetic profiles of patients; the different responses to a particular drug are due, in fact, not only to the specific clinico-pathological features of the patient or to environmental factors, but also to the ethnic origins and the particular individual's genetic profile. Genes which codify for the metabolism enzymes, receptor proteins, or protein targets of chemotherapy agents often present various genetic polymorphisms. The main aim of this review is to provide an overview of the known polymorphisms present in the genes which codify for factors (thymidylate synthase dihydropyrimidine dehydrogenase, uridine diphosphate (UDP)-glucuronosyl-transferase 1A1, enzymes implicated in DNA repair) involved in the action mechanisms of the drugs now utilized in chemotherapeutic treatment of colorectal carcinoma, such as fluoropyrimidines, irinotecan, and platinum agents
Lingua originaleEnglish
pagine (da-a)742-749
Numero di pagine8
RivistaJournal of Cellular Physiology
Stato di pubblicazionePublished - 2005

All Science Journal Classification (ASJC) codes

  • ???subjectarea.asjc.1300.1314???
  • ???subjectarea.asjc.1300.1308???
  • ???subjectarea.asjc.1300.1307???


Entra nei temi di ricerca di 'Pharmacogenomics in colorectal carcinomas: Future perspectives in personalized therapy'. Insieme formano una fingerprint unica.

Cita questo