pH-sensitive hydrogel based on a polyaspartamide derivative

Mandracchia, D.

Risultato della ricerca: Article

17 Citazioni (Scopus)

Abstract

A pH-sensitive hydrogel was prepared by UV irradiation technique. Starting polymer was obtained from alpha,beta-poly (N-2-hydroxyethyl)-DL-aspartamide (PHEA) partially derivatized with glycidyl methacrylate (PHG). The PHG copolymer was cross-linked by UV irradiation in the presence of methacrylic acid (MA) to form a pH sensitive hydrogel. The cross-linked matrix shaped as microparticles was characterized by FT-IR spectrophotometry, XPS, X-ray diffraction, SEM and particle size distribution analyses. Moreover, to have information about water affinity of the prepared sample, swelling measurements were carried out in aqueous media mimicking some biological fluids. In order to employ the prepared network as a pH-sensitive drug delivery system, propionyl-L-carnitine, chosen as a model drug, was entrapped into this hydrogel both during the irradiation process and after cross-linking reaction by a soaking technique. In vitro release studies showed that the drug release rate depends on the different swelling of the network as a function of the environmental pH as well as on the different drug loading method.
Lingua originaleEnglish
pagine (da-a)77-84
Numero di pagine8
RivistaJournal of Drug Delivery Science and Technology
Volume16
Stato di pubblicazionePublished - 2006

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Cita questo

pH-sensitive hydrogel based on a polyaspartamide derivative. / Mandracchia, D.

In: Journal of Drug Delivery Science and Technology, Vol. 16, 2006, pag. 77-84.

Risultato della ricerca: Article

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abstract = "A pH-sensitive hydrogel was prepared by UV irradiation technique. Starting polymer was obtained from alpha,beta-poly (N-2-hydroxyethyl)-DL-aspartamide (PHEA) partially derivatized with glycidyl methacrylate (PHG). The PHG copolymer was cross-linked by UV irradiation in the presence of methacrylic acid (MA) to form a pH sensitive hydrogel. The cross-linked matrix shaped as microparticles was characterized by FT-IR spectrophotometry, XPS, X-ray diffraction, SEM and particle size distribution analyses. Moreover, to have information about water affinity of the prepared sample, swelling measurements were carried out in aqueous media mimicking some biological fluids. In order to employ the prepared network as a pH-sensitive drug delivery system, propionyl-L-carnitine, chosen as a model drug, was entrapped into this hydrogel both during the irradiation process and after cross-linking reaction by a soaking technique. In vitro release studies showed that the drug release rate depends on the different swelling of the network as a function of the environmental pH as well as on the different drug loading method.",
author = "{Mandracchia, D.} and Carlisi, {Bianca Maria} and Gaetano Giammona and Giovanna Pitarresi and Gennara Cavallaro and Craparo, {Emanuela Fabiola}",
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T1 - pH-sensitive hydrogel based on a polyaspartamide derivative

AU - Mandracchia, D.

AU - Carlisi, Bianca Maria

AU - Giammona, Gaetano

AU - Pitarresi, Giovanna

AU - Cavallaro, Gennara

AU - Craparo, Emanuela Fabiola

PY - 2006

Y1 - 2006

N2 - A pH-sensitive hydrogel was prepared by UV irradiation technique. Starting polymer was obtained from alpha,beta-poly (N-2-hydroxyethyl)-DL-aspartamide (PHEA) partially derivatized with glycidyl methacrylate (PHG). The PHG copolymer was cross-linked by UV irradiation in the presence of methacrylic acid (MA) to form a pH sensitive hydrogel. The cross-linked matrix shaped as microparticles was characterized by FT-IR spectrophotometry, XPS, X-ray diffraction, SEM and particle size distribution analyses. Moreover, to have information about water affinity of the prepared sample, swelling measurements were carried out in aqueous media mimicking some biological fluids. In order to employ the prepared network as a pH-sensitive drug delivery system, propionyl-L-carnitine, chosen as a model drug, was entrapped into this hydrogel both during the irradiation process and after cross-linking reaction by a soaking technique. In vitro release studies showed that the drug release rate depends on the different swelling of the network as a function of the environmental pH as well as on the different drug loading method.

AB - A pH-sensitive hydrogel was prepared by UV irradiation technique. Starting polymer was obtained from alpha,beta-poly (N-2-hydroxyethyl)-DL-aspartamide (PHEA) partially derivatized with glycidyl methacrylate (PHG). The PHG copolymer was cross-linked by UV irradiation in the presence of methacrylic acid (MA) to form a pH sensitive hydrogel. The cross-linked matrix shaped as microparticles was characterized by FT-IR spectrophotometry, XPS, X-ray diffraction, SEM and particle size distribution analyses. Moreover, to have information about water affinity of the prepared sample, swelling measurements were carried out in aqueous media mimicking some biological fluids. In order to employ the prepared network as a pH-sensitive drug delivery system, propionyl-L-carnitine, chosen as a model drug, was entrapped into this hydrogel both during the irradiation process and after cross-linking reaction by a soaking technique. In vitro release studies showed that the drug release rate depends on the different swelling of the network as a function of the environmental pH as well as on the different drug loading method.

UR - http://hdl.handle.net/10447/15964

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EP - 84

JO - Journal of Drug Delivery Science and Technology

JF - Journal of Drug Delivery Science and Technology

SN - 1773-2247

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