pH-SENSITIVE HYDROGEL BASED ON A NOVEL PHOTOCROSS-LINKABLE COPOLYMER

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Abstract

A pH sensitive hydrogel has been prepared by a UV irradiation technique. Starting polymer was the PHM (poly hydroxyethylaspartamide methacrylated) oibtained from polyaspartamide (PHEA) partially derivatized with methacrylic anhydride (MA). This new copolymer has been further derivatized with succinic anhydride (SA) to obtain PHM-SA that has been cross-linked by UV irradiation to form a pH sensitive hydrogel. The network, recovered after washing as a powder, has been characterized by FT-IR spectrophotometry and size distribution analysis. Moreover, to have information about water affinity of the prepared sample, swelling measurements have been carried out in aqueous media mimicking biological fluids. The possibility to employ the prepared hydrogel as a pH-sensitive drug delivery system (DDS) has been investigated. In particular, ibuprofen ((S)(+)4-isobutyl--methylphenyl-acetic acid), chosen as a model drug, has been entrapped into PHM-SA hydrogel, and in vitro release studies have showed that its release rate depends on different swelling of the network as a function of the environmental pH.
Lingua originaleEnglish
pagine (da-a)1973-1982
Numero di pagine10
RivistaBiomacromolecules
Volume5(5)
Stato di pubblicazionePublished - 2004

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Hydrogel
Hydrogels
Copolymers
Swelling
Irradiation
Anhydrides
Ibuprofen
Spectrophotometry
Washing
Acetic acid
Acetic Acid
Powders
Polymers
Fluids
Water
Pharmaceutical Preparations
succinic anhydride

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

Cita questo

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title = "pH-SENSITIVE HYDROGEL BASED ON A NOVEL PHOTOCROSS-LINKABLE COPOLYMER",
abstract = "A pH sensitive hydrogel has been prepared by a UV irradiation technique. Starting polymer was the PHM (poly hydroxyethylaspartamide methacrylated) oibtained from polyaspartamide (PHEA) partially derivatized with methacrylic anhydride (MA). This new copolymer has been further derivatized with succinic anhydride (SA) to obtain PHM-SA that has been cross-linked by UV irradiation to form a pH sensitive hydrogel. The network, recovered after washing as a powder, has been characterized by FT-IR spectrophotometry and size distribution analysis. Moreover, to have information about water affinity of the prepared sample, swelling measurements have been carried out in aqueous media mimicking biological fluids. The possibility to employ the prepared hydrogel as a pH-sensitive drug delivery system (DDS) has been investigated. In particular, ibuprofen ((S)(+)4-isobutyl--methylphenyl-acetic acid), chosen as a model drug, has been entrapped into PHM-SA hydrogel, and in vitro release studies have showed that its release rate depends on different swelling of the network as a function of the environmental pH.",
keywords = "drug release, pH sensitive hydrogels, polyaspartamide",
author = "Carlisi, {Bianca Maria} and Palumbo, {Fabio Salvatore} and Giovanna Pitarresi and Gaetano Giammona",
year = "2004",
language = "English",
volume = "5(5)",
pages = "1973--1982",
journal = "Biomacromolecules",
issn = "1525-7797",
publisher = "American Chemical Society",

}

TY - JOUR

T1 - pH-SENSITIVE HYDROGEL BASED ON A NOVEL PHOTOCROSS-LINKABLE COPOLYMER

AU - Carlisi, Bianca Maria

AU - Palumbo, Fabio Salvatore

AU - Pitarresi, Giovanna

AU - Giammona, Gaetano

PY - 2004

Y1 - 2004

N2 - A pH sensitive hydrogel has been prepared by a UV irradiation technique. Starting polymer was the PHM (poly hydroxyethylaspartamide methacrylated) oibtained from polyaspartamide (PHEA) partially derivatized with methacrylic anhydride (MA). This new copolymer has been further derivatized with succinic anhydride (SA) to obtain PHM-SA that has been cross-linked by UV irradiation to form a pH sensitive hydrogel. The network, recovered after washing as a powder, has been characterized by FT-IR spectrophotometry and size distribution analysis. Moreover, to have information about water affinity of the prepared sample, swelling measurements have been carried out in aqueous media mimicking biological fluids. The possibility to employ the prepared hydrogel as a pH-sensitive drug delivery system (DDS) has been investigated. In particular, ibuprofen ((S)(+)4-isobutyl--methylphenyl-acetic acid), chosen as a model drug, has been entrapped into PHM-SA hydrogel, and in vitro release studies have showed that its release rate depends on different swelling of the network as a function of the environmental pH.

AB - A pH sensitive hydrogel has been prepared by a UV irradiation technique. Starting polymer was the PHM (poly hydroxyethylaspartamide methacrylated) oibtained from polyaspartamide (PHEA) partially derivatized with methacrylic anhydride (MA). This new copolymer has been further derivatized with succinic anhydride (SA) to obtain PHM-SA that has been cross-linked by UV irradiation to form a pH sensitive hydrogel. The network, recovered after washing as a powder, has been characterized by FT-IR spectrophotometry and size distribution analysis. Moreover, to have information about water affinity of the prepared sample, swelling measurements have been carried out in aqueous media mimicking biological fluids. The possibility to employ the prepared hydrogel as a pH-sensitive drug delivery system (DDS) has been investigated. In particular, ibuprofen ((S)(+)4-isobutyl--methylphenyl-acetic acid), chosen as a model drug, has been entrapped into PHM-SA hydrogel, and in vitro release studies have showed that its release rate depends on different swelling of the network as a function of the environmental pH.

KW - drug release

KW - pH sensitive hydrogels

KW - polyaspartamide

UR - http://hdl.handle.net/10447/16046

M3 - Article

VL - 5(5)

SP - 1973

EP - 1982

JO - Biomacromolecules

JF - Biomacromolecules

SN - 1525-7797

ER -