Abstract
Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) is a transcriptional coactivator that favorably affects mitochondrial function. This concept is supported by an increasing amount of data including studies in PGC-1α gene-deleted mice, suggesting that PGC-1α is a rescue factor capable of boosting cell metabolism and promoting cell survival. However, this view has now been called into question by a recent study showing that adeno-associated virus-mediated PGC-1α overexpression causes overt cell degeneration in dopaminergic neurons. How is this to be understood, and can these seemingly conflicting findings tell us something about the role of PGC-1α in cell stress and in control of neuronal homeostasis?
Lingua originale | English |
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pagine (da-a) | 2465-2468 |
Numero di pagine | 4 |
Rivista | Cellular and Molecular Life Sciences |
Volume | 69 |
Stato di pubblicazione | Published - 2012 |
All Science Journal Classification (ASJC) codes
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- ???subjectarea.asjc.1300.1312???
- ???subjectarea.asjc.3000.3004???
- ???subjectarea.asjc.2800.2804???
- ???subjectarea.asjc.1300.1307???