PGC-1α: a master gene that is hard to master.

Natale Belluardo, Johanna Mäkelä, Dan Lindholm, Laura Korhonen, Ove Eriksson

Risultato della ricerca: Articlepeer review

26 Citazioni (Scopus)

Abstract

Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) is a transcriptional coactivator that favorably affects mitochondrial function. This concept is supported by an increasing amount of data including studies in PGC-1α gene-deleted mice, suggesting that PGC-1α is a rescue factor capable of boosting cell metabolism and promoting cell survival. However, this view has now been called into question by a recent study showing that adeno-associated virus-mediated PGC-1α overexpression causes overt cell degeneration in dopaminergic neurons. How is this to be understood, and can these seemingly conflicting findings tell us something about the role of PGC-1α in cell stress and in control of neuronal homeostasis?
Lingua originaleEnglish
pagine (da-a)2465-2468
Numero di pagine4
RivistaCellular and Molecular Life Sciences
Volume69
Stato di pubblicazionePublished - 2012

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology

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