TY - JOUR
T1 - Perturbation of metabolic pathways mediates the association of air pollutants with asthma and cardiovascular diseases
AU - Lovison, Gianfranco
AU - Vlaanderen, Jelle
AU - Keski-Rahkonen, Pekka
AU - Grioni, Sara
AU - Galassi, Claudia
AU - Ghantous, Akram
AU - Agnoli, Claudia
AU - Kyrtopoulos, Soterios
AU - Kiss, Agneta
AU - Robinot, Nivonirina
AU - Krogh, Vittorio
AU - Fiorito, Giovanni
AU - Mostafavi, Nahid
AU - Naccarati, Alessio
AU - Jeong, Ayoung
AU - Imboden, Medea
AU - Kiss, Agneta
AU - Vlaanderen, Jelle
AU - Vermeulen, Roel
AU - Kiss, Agneta
AU - Kyrtopoulos, Soterios
AU - Gmuender, Hans
AU - Ranzi, Andrea
AU - Naccarati, Alessio
AU - Sacerdote, Carlotta
AU - Probst-Hensch, Nicole
AU - Herceg, Zdenko
AU - Scalbert, Augustin
AU - Vermeulen, Roel
AU - Vineis, Paolo
PY - 2018
Y1 - 2018
N2 - Background: Epidemiologic evidence indicates common risk factors, including air pollution exposure, for respiratoryand cardiovascular diseases, suggesting the involvement of common altered molecular pathways.Objectives: The goal was to find intermediate metabolites or metabolic pathways that could be associated withboth air pollutants and health outcomes (“meeting-in-the-middle”), thus shedding light on mechanisms andreinforcing causality.Methods: We applied a statistical approach named ‘meet-in-the-middle’ to untargeted metabolomics in two independent case-control studies nested in cohorts on adult-onset asthma (AOA) and cardio-cerebrovascular diseases(CCVD). We compared the results to identify both common and disease-specific altered metabolic pathways.Results: A novel finding was a strong association of AOA with ultrafine particles (UFP; odds ratio 1.80 [1.26,2.55] per increase by 5000 particles/cm3). Further, we have identified several metabolic pathways that potentiallymediate the effect of air pollution on health outcomes. Among those, perturbation of Linoleate metabolismpathway was associated with air pollution exposure, AOA and CCVD. Conclusions: Our results suggest common pathway perturbations may occur as a consequence of chronic exposureto air pollution leading to increased risk for both AOA and CCVD.
AB - Background: Epidemiologic evidence indicates common risk factors, including air pollution exposure, for respiratoryand cardiovascular diseases, suggesting the involvement of common altered molecular pathways.Objectives: The goal was to find intermediate metabolites or metabolic pathways that could be associated withboth air pollutants and health outcomes (“meeting-in-the-middle”), thus shedding light on mechanisms andreinforcing causality.Methods: We applied a statistical approach named ‘meet-in-the-middle’ to untargeted metabolomics in two independent case-control studies nested in cohorts on adult-onset asthma (AOA) and cardio-cerebrovascular diseases(CCVD). We compared the results to identify both common and disease-specific altered metabolic pathways.Results: A novel finding was a strong association of AOA with ultrafine particles (UFP; odds ratio 1.80 [1.26,2.55] per increase by 5000 particles/cm3). Further, we have identified several metabolic pathways that potentiallymediate the effect of air pollution on health outcomes. Among those, perturbation of Linoleate metabolismpathway was associated with air pollution exposure, AOA and CCVD. Conclusions: Our results suggest common pathway perturbations may occur as a consequence of chronic exposureto air pollution leading to increased risk for both AOA and CCVD.
UR - http://hdl.handle.net/10447/314600
M3 - Article
VL - 119
SP - 334
EP - 345
JO - Environmental International
JF - Environmental International
SN - 0160-4120
ER -