Personalized medicine in sleep respiratory disorders; focus on OSA diagnosis and treatment.

Maria Rosaria Bonsignore, Maria R. Bonsignore, Monique C. Suarez Giron, Josep M. Montserrat, Oreste Marrone, Oreste Marrone

Risultato della ricerca: Articlepeer review

28 Citazioni (Scopus)


In all fields of medicine, major efforts are currently dedicated to improve the clinical,physiological and therapeutic understanding of disease, and obstructive sleep apnoea (OSA) is noexception. The personalised medicine approach is relevant for OSA, given its complex pathophysiologyand variable clinical presentation, the interactions with comorbid conditions and its possible contributionto poor outcomes. Treatment with continuous positive airway pressure (CPAP) is effective, but CPAP ispoorly tolerated or not accepted in a considerable proportion of OSA patients. This review summarises theavailable studies on the physiological phenotypes of upper airway response to obstruction during sleep,and the clinical presentations of OSA (phenotypes and clusters) with a special focus on our changingattitudes towards approaches to treatment. Such major efforts are likely to change and expand treatmentoptions for OSA beyond the most common current choices (i.e. CPAP, mandibular advancement devices,positional treatment, lifestyle changes or upper airway surgery). More importantly, treatment for OSA maybecome more effective, being tailored to each patient’s need.
Lingua originaleEnglish
pagine (da-a)00-00
Numero di pagine15
RivistaEuropean Respiratory Review
Stato di pubblicazionePublished - 2017

All Science Journal Classification (ASJC) codes

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