TY - JOUR
T1 - Peroxisome proliferator-activated receptors and atherosclerosis
AU - Nikolic, Dragana
AU - Isenović, Esma R.
AU - Stojanović, Srdan D.
AU - Zarić, Boẑidarka L.
AU - Sudar, Emina M.
AU - Dobutović, Branislava D.
AU - Mikhailidis, Dimitri P.
AU - Soskić, Sanja S.
AU - Nikolić, Dragana M.
AU - Obradović, Milan M.
AU - Stokić, Edita J.
PY - 2011
Y1 - 2011
N2 - The peroxisome proliferator-activated receptors (PPARs) represent the family of 3 nuclear receptor isoforms-PPARα, -γ, and -δ/β, which are encoded by different genes. As lipid sensors, they are primarily involved in regulation of lipid metabolism and subsequently in inflammation and atherosclerosis. Atherosclerosis considers accumulation of the cells and extracellular matrix in the vessel wall leading to the formation of atherosclerotic plaque, atherothrombosis, and other vascular complications. Besides existence of natural ligands for PPARs, their more potent synthetic ligands are fibrates and thiazolidindiones. Future investigations should now focus on the mechanisms of PPARs activation, which might present new approaches involved in the antiatherosclerotic effects revealed in this review. In addition, in this review we are presenting latest data from recent performed clinical studies which have focus on novel approach to PPARs agonists as potential therapeutic agents in the treatment of complex disease such as atherosclerosis. © SAGE Publications 2011.
AB - The peroxisome proliferator-activated receptors (PPARs) represent the family of 3 nuclear receptor isoforms-PPARα, -γ, and -δ/β, which are encoded by different genes. As lipid sensors, they are primarily involved in regulation of lipid metabolism and subsequently in inflammation and atherosclerosis. Atherosclerosis considers accumulation of the cells and extracellular matrix in the vessel wall leading to the formation of atherosclerotic plaque, atherothrombosis, and other vascular complications. Besides existence of natural ligands for PPARs, their more potent synthetic ligands are fibrates and thiazolidindiones. Future investigations should now focus on the mechanisms of PPARs activation, which might present new approaches involved in the antiatherosclerotic effects revealed in this review. In addition, in this review we are presenting latest data from recent performed clinical studies which have focus on novel approach to PPARs agonists as potential therapeutic agents in the treatment of complex disease such as atherosclerosis. © SAGE Publications 2011.
KW - Cardiology and Cardiovascular Medicine
KW - atherosclerosis
KW - atherosclerotic plaque
KW - peroxisome proliferator-activated receptors α
KW - peroxisome proliferator-activated receptors γ
KW - Cardiology and Cardiovascular Medicine
KW - atherosclerosis
KW - atherosclerotic plaque
KW - peroxisome proliferator-activated receptors α
KW - peroxisome proliferator-activated receptors γ
UR - http://hdl.handle.net/10447/197848
M3 - Article
VL - 62
SP - 523
EP - 534
JO - Angiology
JF - Angiology
SN - 0003-3197
ER -