Peroxisome proliferator-activated receptors and atherosclerosis

Dragana Nikolic, Esma R. Isenović, Srdan D. Stojanović, Boẑidarka L. Zarić, Emina M. Sudar, Branislava D. Dobutović, Dimitri P. Mikhailidis, Sanja S. Soskić, Dragana M. Nikolić, Milan M. Obradović, Edita J. Stokić

Risultato della ricerca: Article

25 Citazioni (Scopus)

Abstract

The peroxisome proliferator-activated receptors (PPARs) represent the family of 3 nuclear receptor isoforms-PPARα, -γ, and -δ/β, which are encoded by different genes. As lipid sensors, they are primarily involved in regulation of lipid metabolism and subsequently in inflammation and atherosclerosis. Atherosclerosis considers accumulation of the cells and extracellular matrix in the vessel wall leading to the formation of atherosclerotic plaque, atherothrombosis, and other vascular complications. Besides existence of natural ligands for PPARs, their more potent synthetic ligands are fibrates and thiazolidindiones. Future investigations should now focus on the mechanisms of PPARs activation, which might present new approaches involved in the antiatherosclerotic effects revealed in this review. In addition, in this review we are presenting latest data from recent performed clinical studies which have focus on novel approach to PPARs agonists as potential therapeutic agents in the treatment of complex disease such as atherosclerosis. © SAGE Publications 2011.
Lingua originaleEnglish
pagine (da-a)523-534
Numero di pagine12
RivistaAngiology
Volume62
Stato di pubblicazionePublished - 2011

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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    Nikolic, D., Isenović, E. R., Stojanović, S. D., Zarić, B. L., Sudar, E. M., Dobutović, B. D., Mikhailidis, D. P., Soskić, S. S., Nikolić, D. M., Obradović, M. M., & Stokić, E. J. (2011). Peroxisome proliferator-activated receptors and atherosclerosis. Angiology, 62, 523-534.