Periodontal disease and systemic diseases: interrelationships and interactions

Risultato della ricerca: Chapter

Abstract

The focal infection theory, which for almost half a century justified indiscriminate extraction of teeth to cure focal infections, since the end of the 1940s has become progressively a discarded concept. In parallel with the declining importance assigned to pulp and periapical infections in the pathogenesis of focal diseases, over the last decade there has been increasing interest in the possible relationship between periodontal infection and systemic diseases. Periodontal pathogens and their products, as well as inflammatory mediators produced in gingival tissue, might enter the bloodstream through ulcerated pocket epithelium, causing systemic effects (focal diseases). On the basis of this mechanism, chronic periodontitis has been implicated as risk factor for cardiovascular diseases associated to atherosclerosis, bacterial endocarditis, diabetes mellitus, respiratory disease preterm delivery, rheumatoid arthritis, and more recently osteoporosis, pancreatic cancer, metabolic syndrome, renal diseases and neurodegenerative diseases such as Alzheimer‘s disease. Numerous hypotheses, including common susceptibility, systemic inflammation, direct bacterial infection and cross-reactivity, or molecular mimicry, between bacterial antigens and self-antigens, have been postulated to explain these relationships. In this context, the association of periodontal disease with systemic diseases has introduced the concept of periodontal medicine, which ultimately guides the medical community in therapeutic approaches to improve not only the patient oral health but also systemic health.
Lingua originaleEnglish
Titolo della pubblicazione ospitePeriodontal Disease: Symptoms, Treatment and Prevention
Pagine215-246
Numero di pagine32
Volume2011
Stato di pubblicazionePublished - 2011

Serie di pubblicazioni

NomeDENTAL SCIENCE, MATERIALS AND TECHNOLOGY

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Periodontal Diseases
Focal Infection
Periodontics
Molecular Mimicry
Therapeutic Community
Bacterial Antigens
Bacterial Endocarditis
Chronic Periodontitis
Tooth Extraction
Autoantigens
Oral Health
Infection
Pancreatic Neoplasms
Bacterial Infections
Neurodegenerative Diseases
Osteoporosis
Rheumatoid Arthritis
Atherosclerosis
Diabetes Mellitus
Alzheimer Disease

All Science Journal Classification (ASJC) codes

  • Dentistry(all)

Cita questo

Pizzo, G., Campisi, G., & Guiglia, R. (2011). Periodontal disease and systemic diseases: interrelationships and interactions. In Periodontal Disease: Symptoms, Treatment and Prevention (Vol. 2011, pagg. 215-246). (DENTAL SCIENCE, MATERIALS AND TECHNOLOGY).

Periodontal disease and systemic diseases: interrelationships and interactions. / Pizzo, Giuseppe; Campisi, Giuseppina; Guiglia, Rosario.

Periodontal Disease: Symptoms, Treatment and Prevention. Vol. 2011 2011. pag. 215-246 (DENTAL SCIENCE, MATERIALS AND TECHNOLOGY).

Risultato della ricerca: Chapter

Pizzo, G, Campisi, G & Guiglia, R 2011, Periodontal disease and systemic diseases: interrelationships and interactions. in Periodontal Disease: Symptoms, Treatment and Prevention. vol. 2011, DENTAL SCIENCE, MATERIALS AND TECHNOLOGY, pagg. 215-246.
Pizzo G, Campisi G, Guiglia R. Periodontal disease and systemic diseases: interrelationships and interactions. In Periodontal Disease: Symptoms, Treatment and Prevention. Vol. 2011. 2011. pag. 215-246. (DENTAL SCIENCE, MATERIALS AND TECHNOLOGY).
Pizzo, Giuseppe ; Campisi, Giuseppina ; Guiglia, Rosario. / Periodontal disease and systemic diseases: interrelationships and interactions. Periodontal Disease: Symptoms, Treatment and Prevention. Vol. 2011 2011. pagg. 215-246 (DENTAL SCIENCE, MATERIALS AND TECHNOLOGY).
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