Periodic limb movements during sleep and blood pressure changes in sleep apnoea: Data from the European Sleep Apnoea Database

Maria Rosaria Bonsignore; null Pataka; Ulla Anttalainen; Mehmet S. Tasbakan; Gabriel Roisman; Gabriel Roisman; Gianfranco Parati; Jan Hedner; Jean-Louis Pepin; Marisa R. Bonsignore; null Mcnicholas; Paweł Sliwinski; null Sliwinski; Sophia Schiza; Sofia Schiza; null Ryan; null Kvamme; Davide Soranna; null Steiropoulos; null Bielicki; null Tkacova; Zuzana Dorkova; null Escourrou; Ferran Barbé; null Schulz; Jean Lois Pépin; null Petiet; Ruzena Tkacova; Josep M. Montserrat; Renata Riha; Renata Riha; null Penzel; null Tkacova; null Varoneckas; null Fietze; null Parati; Gianfranco Parati; Oreste Marrone; null Parati; null Hedner; null Parati; Renata Riha; null Riha; null Staats; null Pretl; null Dogas; null Plywaczewski; null Saaresranta; null Verbraecken; null Masa; null Marrone; Ingo Fietze; null Escourrou; Jan Hedner; Antonella Zambon; Ludger Grote; null Grote; null Barbé; Carolina Lombardi; Carolina Lombardi; Holger Hein; null Levy; null Basoglu; Pavol Joppa; null Joppa; null Pepin; Silke Ryan

Periodic limb movements during sleep and blood pressure changes in sleep apnoea: Data from the European Sleep Apnoea Database

Maria Rosaria Bonsignore, Pataka, Ulla Anttalainen, Mehmet S. Tasbakan, Gabriel Roisman, Gabriel Roisman, Gianfranco Parati, Jan Hedner, Jean-Louis Pepin, Marisa R. Bonsignore, Mcnicholas, Paweł Sliwinski, Sliwinski, Sophia Schiza, Sofia Schiza, Ryan, Kvamme, Davide Soranna, Steiropoulos, BielickiTkacova, Zuzana Dorkova, Escourrou, Ferran Barbé, Schulz, Jean Lois Pépin, Petiet, Ruzena Tkacova, Josep M. Montserrat, Renata Riha, Renata Riha, Penzel, Tkacova, Varoneckas, Fietze, Parati, Gianfranco Parati, Oreste Marrone, Parati, Hedner, Parati, Renata Riha, Riha, Staats, Pretl, Dogas, Plywaczewski, Saaresranta, Verbraecken, Masa, Marrone, Ingo Fietze, Escourrou, Jan Hedner, Antonella Zambon, Ludger Grote, Grote, Barbé, Carolina Lombardi, Carolina Lombardi, Holger Hein, Levy, Basoglu, Pavol Joppa, Joppa, Pepin, Silke Ryan

Promozione della Salute, Materno-Infantile, di Medicina Interna e Specialistica di Eccellenza “G. D’Alessandro”

Risultato della ricerca: Article › peer review

1 Citazioni (Scopus)

Abstract

Background and objective: OSA and PLMS are known to induce acute BP swings during sleep. Our current study aimed to address the independent effect of PLMS on BP in an unselected OSA patient cohort. Methods: This cross-sectional analysis included 1487 patients (1110 males, no previous hypertension diagnosis or treatment, mean age: 52.5 years, mean BMI: 30.5 kg/m2) with significant OSA (defined as AHI ≥ 10) recruited from the European Sleep Apnoea Cohort. Patients underwent overnight PSG. Patients were stratified into two groups: patients with significant PLMS (PLMSI > 25 events/hour of sleep) and patients without significant PLMS (PLMSI < 25 events/hour of sleep). SBP, DBP and PP were the variables of interest. For each of these, a multivariate regression linear model was fitted to evaluate the relationship between PLMS and outcome adjusting for sociodemographic and clinical covariates (gender, age, BMI, AHI, ESS, diabetes, smoking and sleep efficiency). Results: The univariate analysis of SBP showed an increment of BP equal to 4.70 mm Hg (P < 0.001) in patients with significant PLMS compared to patients without significant PLMS. This increment remained significant after implementing a multivariate regression model (2.64 mm Hg, P = 0.044). No significant increment of BP was observed for DBP and PP. Conclusion: PLMS is associated with a rise in SBP regardless of AHI, independent of clinical and sociodemographic confounders. A PLMS phenotype may carry an increased risk for cardiovascular disease in OSA patients.

Lingua originale	English
Numero di pagine	8
Rivista	Respirology
Stato di pubblicazione	Published - 2019

All Science Journal Classification (ASJC) codes

Pulmonary and Respiratory Medicine

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Cita questo

Bonsignore, M. R., Pataka, Anttalainen, U., Tasbakan, M. S., Roisman, G., Roisman, G., Parati, G., Hedner, J., Pepin, J-L., Bonsignore, M. R., Mcnicholas, Sliwinski, P., Sliwinski, Schiza, S., Schiza, S., Ryan, Kvamme, Soranna, D., Steiropoulos, ... Ryan, S. (2019). Periodic limb movements during sleep and blood pressure changes in sleep apnoea: Data from the European Sleep Apnoea Database. Respirology.

Periodic limb movements during sleep and blood pressure changes in sleep apnoea: Data from the European Sleep Apnoea Database. / Bonsignore, Maria Rosaria; Pataka; Anttalainen, Ulla; Tasbakan, Mehmet S.; Roisman, Gabriel; Roisman, Gabriel; Parati, Gianfranco; Hedner, Jan; Pepin, Jean-Louis; Bonsignore, Marisa R.; Mcnicholas; Sliwinski, Paweł; Sliwinski; Schiza, Sophia; Schiza, Sofia; Ryan; Kvamme; Soranna, Davide; Steiropoulos; Bielicki; Tkacova; Dorkova, Zuzana; Escourrou; Barbé, Ferran; Schulz; Pépin, Jean Lois; Petiet; Tkacova, Ruzena; Montserrat, Josep M.; Riha, Renata; Riha, Renata; Penzel; Tkacova; Varoneckas; Fietze; Parati; Parati, Gianfranco; Marrone, Oreste; Parati; Hedner; Parati; Riha, Renata; Riha; Staats; Pretl; Dogas; Plywaczewski; Saaresranta; Verbraecken; Masa; Marrone; Fietze, Ingo; Escourrou; Hedner, Jan; Zambon, Antonella; Grote, Ludger; Grote; Barbé; Lombardi, Carolina; Lombardi, Carolina; Hein, Holger; Levy; Basoglu; Joppa, Pavol; Joppa; Pepin; Ryan, Silke.

In: Respirology, 2019.

Risultato della ricerca: Article › peer review

Bonsignore, MR, Pataka, Anttalainen, U, Tasbakan, MS, Roisman, G, Roisman, G, Parati, G, Hedner, J, Pepin, J-L, Bonsignore, MR, Mcnicholas, Sliwinski, P, Sliwinski, Schiza, S, Schiza, S, Ryan, Kvamme, Soranna, D, Steiropoulos, Bielicki, Tkacova, Dorkova, Z, Escourrou, Barbé, F, Schulz, Pépin, JL, Petiet, Tkacova, R, Montserrat, JM, Riha, R, Riha, R, Penzel, Tkacova, Varoneckas, Fietze, Parati, Parati, G, Marrone, O, Parati, Hedner, Parati, Riha, R, Riha, Staats, Pretl, Dogas, Plywaczewski, Saaresranta, Verbraecken, Masa, Marrone, Fietze, I, Escourrou, Hedner, J, Zambon, A, Grote, L, Grote, Barbé, Lombardi, C, Lombardi, C, Hein, H, Levy, Basoglu, Joppa, P, Joppa, Pepin & Ryan, S 2019, 'Periodic limb movements during sleep and blood pressure changes in sleep apnoea: Data from the European Sleep Apnoea Database', Respirology.

Bonsignore, Maria Rosaria ; Pataka ; Anttalainen, Ulla ; Tasbakan, Mehmet S. ; Roisman, Gabriel ; Roisman, Gabriel ; Parati, Gianfranco ; Hedner, Jan ; Pepin, Jean-Louis ; Bonsignore, Marisa R. ; Mcnicholas ; Sliwinski, Paweł ; Sliwinski ; Schiza, Sophia ; Schiza, Sofia ; Ryan ; Kvamme ; Soranna, Davide ; Steiropoulos ; Bielicki ; Tkacova ; Dorkova, Zuzana ; Escourrou ; Barbé, Ferran ; Schulz ; Pépin, Jean Lois ; Petiet ; Tkacova, Ruzena ; Montserrat, Josep M. ; Riha, Renata ; Riha, Renata ; Penzel ; Tkacova ; Varoneckas ; Fietze ; Parati ; Parati, Gianfranco ; Marrone, Oreste ; Parati ; Hedner ; Parati ; Riha, Renata ; Riha ; Staats ; Pretl ; Dogas ; Plywaczewski ; Saaresranta ; Verbraecken ; Masa ; Marrone ; Fietze, Ingo ; Escourrou ; Hedner, Jan ; Zambon, Antonella ; Grote, Ludger ; Grote ; Barbé ; Lombardi, Carolina ; Lombardi, Carolina ; Hein, Holger ; Levy ; Basoglu ; Joppa, Pavol ; Joppa ; Pepin ; Ryan, Silke. / Periodic limb movements during sleep and blood pressure changes in sleep apnoea: Data from the European Sleep Apnoea Database. In: Respirology. 2019.

@article{14782a4fc33b4468b588cdddab152623,

title = "Periodic limb movements during sleep and blood pressure changes in sleep apnoea: Data from the European Sleep Apnoea Database",

abstract = "Background and objective: OSA and PLMS are known to induce acute BP swings during sleep. Our current study aimed to address the independent effect of PLMS on BP in an unselected OSA patient cohort. Methods: This cross-sectional analysis included 1487 patients (1110 males, no previous hypertension diagnosis or treatment, mean age: 52.5 years, mean BMI: 30.5 kg/m2) with significant OSA (defined as AHI ≥ 10) recruited from the European Sleep Apnoea Cohort. Patients underwent overnight PSG. Patients were stratified into two groups: patients with significant PLMS (PLMSI > 25 events/hour of sleep) and patients without significant PLMS (PLMSI < 25 events/hour of sleep). SBP, DBP and PP were the variables of interest. For each of these, a multivariate regression linear model was fitted to evaluate the relationship between PLMS and outcome adjusting for sociodemographic and clinical covariates (gender, age, BMI, AHI, ESS, diabetes, smoking and sleep efficiency). Results: The univariate analysis of SBP showed an increment of BP equal to 4.70 mm Hg (P < 0.001) in patients with significant PLMS compared to patients without significant PLMS. This increment remained significant after implementing a multivariate regression model (2.64 mm Hg, P = 0.044). No significant increment of BP was observed for DBP and PP. Conclusion: PLMS is associated with a rise in SBP regardless of AHI, independent of clinical and sociodemographic confounders. A PLMS phenotype may carry an increased risk for cardiovascular disease in OSA patients.",

author = "Bonsignore, {Maria Rosaria} and Pataka and Ulla Anttalainen and Tasbakan, {Mehmet S.} and Gabriel Roisman and Gabriel Roisman and Gianfranco Parati and Jan Hedner and Jean-Louis Pepin and Bonsignore, {Marisa R.} and Mcnicholas and Pawe{\l} Sliwinski and Sliwinski and Sophia Schiza and Sofia Schiza and Ryan and Kvamme and Davide Soranna and Steiropoulos and Bielicki and Tkacova and Zuzana Dorkova and Escourrou and Ferran Barb{\'e} and Schulz and P{\'e}pin, {Jean Lois} and Petiet and Ruzena Tkacova and Montserrat, {Josep M.} and Renata Riha and Renata Riha and Penzel and Tkacova and Varoneckas and Fietze and Parati and Gianfranco Parati and Oreste Marrone and Parati and Hedner and Parati and Renata Riha and Riha and Staats and Pretl and Dogas and Plywaczewski and Saaresranta and Verbraecken and Masa and Marrone and Ingo Fietze and Escourrou and Jan Hedner and Antonella Zambon and Ludger Grote and Grote and Barb{\'e} and Carolina Lombardi and Carolina Lombardi and Holger Hein and Levy and Basoglu and Pavol Joppa and Joppa and Pepin and Silke Ryan",

year = "2019",

language = "English",

journal = "Respirology",

issn = "1323-7799",

publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - Periodic limb movements during sleep and blood pressure changes in sleep apnoea: Data from the European Sleep Apnoea Database

AU - Bonsignore, Maria Rosaria

AU - Pataka, null

AU - Anttalainen, Ulla

AU - Tasbakan, Mehmet S.

AU - Roisman, Gabriel

AU - Parati, Gianfranco

AU - Hedner, Jan

AU - Pepin, Jean-Louis

AU - Bonsignore, Marisa R.

AU - Mcnicholas, null

AU - Sliwinski, Paweł

AU - Sliwinski, null

AU - Schiza, Sophia

AU - Schiza, Sofia

AU - Ryan, null

AU - Kvamme, null

AU - Soranna, Davide

AU - Steiropoulos, null

AU - Bielicki, null

AU - Tkacova, null

AU - Dorkova, Zuzana

AU - Escourrou, null

AU - Barbé, Ferran

AU - Schulz, null

AU - Pépin, Jean Lois

AU - Petiet, null

AU - Tkacova, Ruzena

AU - Montserrat, Josep M.

AU - Riha, Renata

AU - Penzel, null

AU - Tkacova, null

AU - Varoneckas, null

AU - Fietze, null

AU - Parati, null

AU - Parati, Gianfranco

AU - Marrone, Oreste

AU - Parati, null

AU - Hedner, null

AU - Parati, null

AU - Riha, Renata

AU - Riha, null

AU - Staats, null

AU - Pretl, null

AU - Dogas, null

AU - Plywaczewski, null

AU - Saaresranta, null

AU - Verbraecken, null

AU - Masa, null

AU - Marrone, null

AU - Fietze, Ingo

AU - Escourrou, null

AU - Hedner, Jan

AU - Zambon, Antonella

AU - Grote, Ludger

AU - Grote, null

AU - Barbé, null

AU - Lombardi, Carolina

AU - Hein, Holger

AU - Levy, null

AU - Basoglu, null

AU - Joppa, Pavol

AU - Joppa, null

AU - Pepin, null

AU - Ryan, Silke

PY - 2019

Y1 - 2019

N2 - Background and objective: OSA and PLMS are known to induce acute BP swings during sleep. Our current study aimed to address the independent effect of PLMS on BP in an unselected OSA patient cohort. Methods: This cross-sectional analysis included 1487 patients (1110 males, no previous hypertension diagnosis or treatment, mean age: 52.5 years, mean BMI: 30.5 kg/m2) with significant OSA (defined as AHI ≥ 10) recruited from the European Sleep Apnoea Cohort. Patients underwent overnight PSG. Patients were stratified into two groups: patients with significant PLMS (PLMSI > 25 events/hour of sleep) and patients without significant PLMS (PLMSI < 25 events/hour of sleep). SBP, DBP and PP were the variables of interest. For each of these, a multivariate regression linear model was fitted to evaluate the relationship between PLMS and outcome adjusting for sociodemographic and clinical covariates (gender, age, BMI, AHI, ESS, diabetes, smoking and sleep efficiency). Results: The univariate analysis of SBP showed an increment of BP equal to 4.70 mm Hg (P < 0.001) in patients with significant PLMS compared to patients without significant PLMS. This increment remained significant after implementing a multivariate regression model (2.64 mm Hg, P = 0.044). No significant increment of BP was observed for DBP and PP. Conclusion: PLMS is associated with a rise in SBP regardless of AHI, independent of clinical and sociodemographic confounders. A PLMS phenotype may carry an increased risk for cardiovascular disease in OSA patients.

AB - Background and objective: OSA and PLMS are known to induce acute BP swings during sleep. Our current study aimed to address the independent effect of PLMS on BP in an unselected OSA patient cohort. Methods: This cross-sectional analysis included 1487 patients (1110 males, no previous hypertension diagnosis or treatment, mean age: 52.5 years, mean BMI: 30.5 kg/m2) with significant OSA (defined as AHI ≥ 10) recruited from the European Sleep Apnoea Cohort. Patients underwent overnight PSG. Patients were stratified into two groups: patients with significant PLMS (PLMSI > 25 events/hour of sleep) and patients without significant PLMS (PLMSI < 25 events/hour of sleep). SBP, DBP and PP were the variables of interest. For each of these, a multivariate regression linear model was fitted to evaluate the relationship between PLMS and outcome adjusting for sociodemographic and clinical covariates (gender, age, BMI, AHI, ESS, diabetes, smoking and sleep efficiency). Results: The univariate analysis of SBP showed an increment of BP equal to 4.70 mm Hg (P < 0.001) in patients with significant PLMS compared to patients without significant PLMS. This increment remained significant after implementing a multivariate regression model (2.64 mm Hg, P = 0.044). No significant increment of BP was observed for DBP and PP. Conclusion: PLMS is associated with a rise in SBP regardless of AHI, independent of clinical and sociodemographic confounders. A PLMS phenotype may carry an increased risk for cardiovascular disease in OSA patients.

UR - http://hdl.handle.net/10447/401712

UR - http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1440-1843

M3 - Article

JO - Respirology

JF - Respirology

SN - 1323-7799

ER -