Perfusion computed tomography of intracranial meningiomas: In vivo correlation of cerebral blood volume and vascular permeability

Giovanni Grasso, Francesca Granata, Valeria Barresi, Rosa Morabito, Enricomaria Mormina, Alessandro Calamuneri, Marcello Longo, Sergio Vinci, Concetta Alafaci, Francesco Maria Salpietro, Francesco Tomasello

Risultato della ricerca: Articlepeer review

5 Citazioni (Scopus)

Abstract

Background: A noninvasive method to predict the grade of a meningioma would be desirable since it would anticipate information about tumour nature, recurrence and improve tumour management and outcomes. The aim of the present study was to assess the ability of perfusion computed tomography (PCT) technique in predicting the meningioma grade before surgery. Data from PCT, such as cerebral blood volume (CBV) and permeability surface (PS), were correlated with immunohistolopathological information. Methods: Twenty-three patients with a diagnosis of intracranial meningioma underwent PCT for pre-surgical evaluation of CBV and PS. During surgery, samples from the centre and periphery of the tumour were obtained. Two correspondent regions of interest (ROIs) were drawn on CBV and PS maps. Central and peripheral CBV and PS mean values were calculated. PCT parameters were correlated to CD-34 and endoglin. Results: There was a positive correlation between PS and CD-34. No correlation was found between PS values and endoglin, CBV values and CD-34 and endoglin values. Conclusion: Our findings suggest that PCT may support conventional morphological imaging in predicting meningioma grading before surgery.
Lingua originaleEnglish
pagine (da-a)303-309
Numero di pagine7
RivistaTHE NEURORADIOLOGY JOURNAL
Volume28
Stato di pubblicazionePublished - 2015

All Science Journal Classification (ASJC) codes

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