Performance evaluation of a newly developed molecular assay for the accurate diagnosis of gastroenteritis associated with norovirus of genogroup II

Simona De Grazia, Giovanni Giammanco, Floriana Bonura, Noemi Urone, Vincenzo Cappa

Risultato della ricerca: Articlepeer review

1 Citazioni (Scopus)

Abstract

The performance of a newly proposed fully automated cassette-based sample-to-results solution for norovirus (NoV) detection, InGenius Norovirus ELITe MGB®, was evaluated. A total of 120 selected archival stool samples from children hospitalized for acute gastroenteritis were used to compare the results to a reference real-time RT-PCR. The InGenius NoV assay showed optimal diagnostic accuracy (sensitivity, 100%; specificity, 95.7%) and was able to correctly detect the entire wide panel of epidemiologically relevant genotypes tested. These preliminary results suggest that the InGenius NoV assay can be recommended as a valuable method for accurate diagnosis of NoV GII infection in epidemic and sporadic gastroenteritis.
Lingua originaleEnglish
pagine (da-a)3377-3381
Numero di pagine5
RivistaArchives of Virology
Volume163
Stato di pubblicazionePublished - 2018

All Science Journal Classification (ASJC) codes

  • Virology

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