PEG-benzofulvene copolymer hydrogels for antibody delivery

Mariano Licciardi, Gaetano Giammona, Salvatore Valenti, Mariano Licciardi, Mauro Di Stefano, Mario Grassi, Gaetano Giammona, Andrea Cappelli, Germano Giuliani, Luigi Feruglio

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Poly[monomethylnona(ethylene glycol) 1-methylene-3-(4-methylphenyl)-1H-indene-2-carboxylate](poly-1b) a new polymer based on a PEG-functionalized benzofulvene macromonomer have been investigatedas hydrogel-based material for complexation and release of immunoglobulin (IgG) at physiologicalmimicking conditions.The polymer ability to complex human IgG has been studied by preparing copolymer/protein complexesobtained by spontaneous protein interactions onto polymer hydrogel aggregates, and the proteinrelease rate has been evaluated at physiological conditions. SEM analysis was used to visualize thecopolymer/IgG aggregates and its microstructured deposition. Moreover, rheological studies performedat 37 ◦C allowed determining hydrogel mechanical properties. On the basis of these information and NMRtransverse relaxation measurements, the estimation of hydrogel mesh size distribution was possible.Finally, biological studies performed with poly-1b aqueous dispersions showed no cytotoxic effect onMCF-7 cell line, suggesting potential biocompatibility features for this polymer and making this newpolymer a good potential candidate for the production of drug delivery systems.
Lingua originaleEnglish
Numero di pagine8
RivistaInternational Journal of Pharmaceutics
Stato di pubblicazionePublished - 2010


All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

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Licciardi, M., Giammona, G., Valenti, S., Licciardi, M., Di Stefano, M., Grassi, M., Giammona, G., Cappelli, A., Giuliani, G., & Feruglio, L. (2010). PEG-benzofulvene copolymer hydrogels for antibody delivery. International Journal of Pharmaceutics, 2010.