PCOS and infertility. Metformin administration and ovulation induction in patients with reproductive failures. Preliminary data.

Alessandra Vassiliadis, Carlomagno, Unfer

Risultato della ricerca: Article


The aim of this study is to investigate the effects of the metformin administration in patients with previous reproductive failures.Inclusion criteria: 13 patients with chronic anovulation and PCOS, age < 38 years old, sterility not less than 2 years, C.C. resistance, conception failure in previous cycles with only r-FSH and negativity to the multiple miscarriages tests, absence of others infertility factors.Metformin administration started 2 months before the ovulation induction.Alternatively a spontaneous menstruation it was induced by progestin.Ovulation was performed with r-FSH and patients were invited to have sexual intercourse during the 48h after the HCG trigger. Luteal support was administrated.Results showed 100% of ovulatory cycles, 5 pregnancies and only 1 lost.Few side effects.
Lingua originaleEnglish
pagine (da-a)443-447
Numero di pagine5
RivistaGiornale Italiano di Ostetricia e Ginecologia
Stato di pubblicazionePublished - 2014


All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynaecology

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