The aim of this study is to investigate the effects of the metformin administration in patients with previous reproductive failures.Inclusion criteria: 13 patients with chronic anovulation and PCOS, age < 38 years old, sterility not less than 2 years, C.C. resistance, conception failure in previous cycles with only r-FSH and negativity to the multiple miscarriages tests, absence of others infertility factors.Metformin administration started 2 months before the ovulation induction.Alternatively a spontaneous menstruation it was induced by progestin.Ovulation was performed with r-FSH and patients were invited to have sexual intercourse during the 48h after the HCG trigger. Luteal support was administrated.Results showed 100% of ovulatory cycles, 5 pregnancies and only 1 lost.Few side effects.
|Numero di pagine||5|
|Rivista||Giornale Italiano di Ostetricia e Ginecologia|
|Stato di pubblicazione||Published - 2014|
All Science Journal Classification (ASJC) codes
- Obstetrics and Gynaecology
Vassiliadis, A., Carlomagno, & Unfer (2014). PCOS and infertility. Metformin administration and ovulation induction in patients with reproductive failures. Preliminary data. Giornale Italiano di Ostetricia e Ginecologia, XXXVI, 443-447.