Patterns of transmitted HIV drug resistance in Europe vary by risk group.

Fabio Tramuto, Claudia Kücherer, Dan Otelea, Algirdas Griskevicius, Jurgen Vercauteren, Daniel Struck, Dineke Frentz, Anne-Mieke Vandamme, Charles Boucher, Mario Poljak, Danica Stanekova, Kirsi Liitsola Marek Linka, Claus Nielsen, David Van De Vijver, Maja Stanojevic, Andrzej Horban, Tatjana Kolupajeva, Danail Beshkov, Annemarie Wensing, Osamah HamoudaDimitrios Paraskevis, Leondios Kostrikis, Elisabeth Puchhammer-Stöckl, Claudia Balotta, Colm Bergin, Anders Sönnerborg, Zehava Grossman, Klaus Korn, Birgitta Åsjö, Roger Paredes, Bonaventura Clotet, Jean-Claude Schmit, Louise Jørgensen, Jan Albert, Ana Abecasis, Ricardo Camacho

Risultato della ricerca: Articlepeer review

27 Citazioni (Scopus)

Abstract

Background: In Europe, a continuous programme (SPREAD) has been in place for ten years to study transmission of drug resistant HIV. We analysed time trends of transmitted drug resistance mutations (TDRM) in relation to the risk behaviour reported.Methods: HIV-1 patients newly diagnosed in 27 countries from 2002 through 2007 were included. Inclusion was representative for risk group and geographical distribution in the participating countries in Europe. Trends over time were calculated by logistic regression.Results: From the 4317 patients included, the majority was men-having-sex-with-men -MSM (2084, 48%), followed by heterosexuals (1501, 35%) and injection drug users (IDU) (355, 8%). MSM were more often from Western Europe origin, infected with subtype B virus, and recently infected (,1 year) (p,0.001). The prevalence of TDRM was highest in MSM (prevalence of 11.1%), followed by heterosexuals (6.6%) and IDU (5.1%, p,0.001). TDRM was predominantly ascribed to nucleoside reverse transcriptase inhibitors (NRTI) with a prevalence of 6.6% in MSM, 3.3% in heterosexuals and 2.0% in IDU (p = 0.001). A significant increase in resistance to non- nucleoside reverse transcriptase inhibitors (NNRTIs) and a decrease in resistance to protease inhibitors was observed in MSM (p=0.008 and p=0.006, respectively), but not in heterosexual patients (p = 0.68 and p = 0.14, respectively).Conclusions: MSM showed to have significantly higher TDRM prevalence compared to heterosexuals and IDU. The increasing NNRTI resistance in MSM is likely to negatively influence the therapy response of first-line therapy, as most include NNRTI drugs.
Lingua originaleEnglish
Numero di pagine7
RivistaPLoS One
Volume9
Stato di pubblicazionePublished - 2014

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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