In older adults infections are among the leading causes ofemergency department visits, hospitalization, morbidityand mortality [1–3]. Infections also occur as adverse eventsduring hospitalization, as highlighted by the large use ofantibiotics in this setting, resulting in an increase of hospitalizationlength and mortality rate [4–6]. There is a paucityof studies, especially in European countries, that did offera general pattern on all the types of infections occurringin acutely hospitalized older patients, being the literaturemainly focused on single type of infections (i.e. pneumoniaand urinary tract infections). To fill this gap of knowledge,we chose to observe and describe the prevalence and typesof infections in a large cohort of older hospitalized patientsin the frame of REPOSI (REgistro POliterapie SIMI) register.