Pathophysiology of Peripheral Arterial Disease (PAD): A Review on Oxidative Disorders

Domenico Di Raimondo, Salvatore Scuto, Salvatore Santo Signorelli, Salvatore Santo Signorelli, Elisa Marino, Salvatore Santo Signorelli

Risultato della ricerca: Articlepeer review

2 Citazioni (Scopus)

Abstract

Peripheral arterial disease (PAD) is an atherosclerotic disease that affects a wide range of the world's population, reaching up to 200 million individuals worldwide. PAD particularly affects elderly individuals (>65 years old). PAD is often underdiagnosed or underestimated, although specificity in diagnosis is shown by an ankle/brachial approach, and the high cardiovascular event risk that affected the PAD patients. A number of pathophysiologic pathways operate in chronic arterial ischemia of lower limbs, giving the possibility to improve therapeutic strategies and the outcome of patients. This review aims to provide a well detailed description of such fundamental issues as physical exercise, biochemistry of physical exercise, skeletal muscle in PAD, heme oxygenase 1 (HO-1) in PAD, and antioxidants in PAD. These issues are closely related to the oxidative stress in PAD. We want to draw attention to the pathophysiologic pathways that are considered to be beneficial in order to achieve more effective options to treat PAD patients.
Lingua originaleEnglish
pagine (da-a)4393-
Numero di pagine14
RivistaInternational Journal of Molecular Sciences
Volume21
Stato di pubblicazionePublished - 2020

All Science Journal Classification (ASJC) codes

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