Pathological implications of Th1/Th2 cytokine geneticvariants in Behçet's disease: Data from a pilot study in a Sicilian population

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Abstract

Cytokines act as pleiotropic polypeptides able to regulate inflammatory/immune responses and to provide important signals in physiological and pathological processes. Several cytokines (Th1, Th2, and Th17) seem to be involved in the pathophysiology of Behçet's disease, a chronic immune-mediated disease characterized by oral and genital lesions and ocular inflammation. Its individual susceptibility seems to be modulated by genetic variants in genes codifying these cytokines. Th1 and Th17 seem to be involved in the disease's active phases, and Th2 seems to affect the development or severity of the disease; however, contrasting data are reported. In this study, some genetic variants of the Th1/Th2 cytokine genes were investigated in Sicilian patients and age- and gender-matched controls. Three very significant associations with Behçet's disease were detected, and combined genotypes associated with increased disease risk were identified. Results obtained point to the key role of Th1/Th2 cytokine genetic variants in disease susceptibility.
Lingua originaleEnglish
pagine (da-a)967-975
Numero di pagine9
RivistaBiochemical Genetics
Volume51
Stato di pubblicazionePublished - 2013

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cytokines
Cytokines
Population
Physiological Phenomena
Disease Susceptibility
Immune System Diseases
Genes
Pathologic Processes
pathophysiology
chronic diseases
lesions (animal)
disease severity
genitalia
disease resistance
mouth
polypeptides
gene
Chronic Disease
genes
inflammation

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics
  • Biochemistry
  • Molecular Biology
  • Genetics

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title = "Pathological implications of Th1/Th2 cytokine geneticvariants in Beh{\cc}et's disease: Data from a pilot study in a Sicilian population",
abstract = "Cytokines act as pleiotropic polypeptides able to regulate inflammatory/immune responses and to provide important signals in physiological and pathological processes. Several cytokines (Th1, Th2, and Th17) seem to be involved in the pathophysiology of Beh{\cc}et's disease, a chronic immune-mediated disease characterized by oral and genital lesions and ocular inflammation. Its individual susceptibility seems to be modulated by genetic variants in genes codifying these cytokines. Th1 and Th17 seem to be involved in the disease's active phases, and Th2 seems to affect the development or severity of the disease; however, contrasting data are reported. In this study, some genetic variants of the Th1/Th2 cytokine genes were investigated in Sicilian patients and age- and gender-matched controls. Three very significant associations with Beh{\cc}et's disease were detected, and combined genotypes associated with increased disease risk were identified. Results obtained point to the key role of Th1/Th2 cytokine genetic variants in disease susceptibility.",
author = "Marisa Palmeri and Loredana Vaccarino and Giovanni Triolo and Giuseppina Candore and Domenico Lio and Letizia Scola and Balistreri, {Carmela Rita}",
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journal = "Biochemical Genetics",
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TY - JOUR

T1 - Pathological implications of Th1/Th2 cytokine geneticvariants in Behçet's disease: Data from a pilot study in a Sicilian population

AU - Palmeri, Marisa

AU - Vaccarino, Loredana

AU - Triolo, Giovanni

AU - Candore, Giuseppina

AU - Lio, Domenico

AU - Scola, Letizia

AU - Balistreri, Carmela Rita

PY - 2013

Y1 - 2013

N2 - Cytokines act as pleiotropic polypeptides able to regulate inflammatory/immune responses and to provide important signals in physiological and pathological processes. Several cytokines (Th1, Th2, and Th17) seem to be involved in the pathophysiology of Behçet's disease, a chronic immune-mediated disease characterized by oral and genital lesions and ocular inflammation. Its individual susceptibility seems to be modulated by genetic variants in genes codifying these cytokines. Th1 and Th17 seem to be involved in the disease's active phases, and Th2 seems to affect the development or severity of the disease; however, contrasting data are reported. In this study, some genetic variants of the Th1/Th2 cytokine genes were investigated in Sicilian patients and age- and gender-matched controls. Three very significant associations with Behçet's disease were detected, and combined genotypes associated with increased disease risk were identified. Results obtained point to the key role of Th1/Th2 cytokine genetic variants in disease susceptibility.

AB - Cytokines act as pleiotropic polypeptides able to regulate inflammatory/immune responses and to provide important signals in physiological and pathological processes. Several cytokines (Th1, Th2, and Th17) seem to be involved in the pathophysiology of Behçet's disease, a chronic immune-mediated disease characterized by oral and genital lesions and ocular inflammation. Its individual susceptibility seems to be modulated by genetic variants in genes codifying these cytokines. Th1 and Th17 seem to be involved in the disease's active phases, and Th2 seems to affect the development or severity of the disease; however, contrasting data are reported. In this study, some genetic variants of the Th1/Th2 cytokine genes were investigated in Sicilian patients and age- and gender-matched controls. Three very significant associations with Behçet's disease were detected, and combined genotypes associated with increased disease risk were identified. Results obtained point to the key role of Th1/Th2 cytokine genetic variants in disease susceptibility.

UR - http://hdl.handle.net/10447/90854

M3 - Article

VL - 51

SP - 967

EP - 975

JO - Biochemical Genetics

JF - Biochemical Genetics

SN - 0006-2928

ER -