Rosa Lo Baido, Salvatore Novo, Vincenzo Abrignani, Maurizio G. Abrignani

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8 Citazioni (Scopus)


Different data indicate that psychological and/or emotional disorders may play an important role in the naturalhistory of heart diseases. Although the major evidence is that related to depression, epidemiological data would indicatethat anxiety and panic disorders are highly represented in cardiac patient, thus influencing mortality and morbidity.The diagnosis of panic disorder in patients with chest pain is crucial to a correct therapeutic approach, as well as toreduce the risks and costs of inappropriate treatments.Anxiety and panic may accelerate different direct and indirect processes involved in the pathogenesis ofcardiovascular diseases: lifestyle risk factors, arterial hypertension, myocardial perfusion, autonomic nervous system orhypothalamus-pituitary-adrenal axis, platelet activation, and inflammation processes. Panic disorder seems to correlateparticularly with sudden death: this suggests that it may be considered one of the main inducers of life-threateningarrhythmias, rather than to be linked to the development and progression of coronary atherosclerosis.Beyond hard outcomes, panic disorders produce negative effects on both global adjustment and life quality thatmay impair the course of the cardiac diseases. Interestingly, specific antipanic and anxiolytic agents seem to beparticularly effective upon life quality. In any case, adequate controlled clinical trials are necessary in order to confirmthe possibility of cardiovascular risk reduction by means of anxiety and panic disorder treatment.
Lingua originaleEnglish
pagine (da-a)130-144
Numero di pagine15
RivistaClinical Neuropsychiatry
Stato di pubblicazionePublished - 2014

All Science Journal Classification (ASJC) codes

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