Pallidotomy improves quality of life in selected parkinsonian patients: an Italian report.

Domenico Iacopino, Riccardo Lo Presti, Domenico G. Iacopino, Sebastiano Lucerna, Paolo Di Bella, Edoardo Sessa, Francesco M. Salpietro, Placido Bramanti, Francesco Tomasello, Cole A. Giller

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3 Citazioni (Scopus)

Abstract

Pallidotomy has recently been reconfirmed as effective for otherwise intractable symptoms of Parkinson's disease. Nonetheless almost every aspect of its performance requires choices which are not fully established and may vary between centers. These include: 1) patient selection; 2) choice of imaging modality, 3) choice of anatomic landmarks for targeting the lesion, 4) choice of method for physiologic confirmation of location, 5) choice of lesion size and shape. We present two cases of pallidotomy procedures in Parkinsonian patients that in our knowledge are the first reported in Italy. Our experience and a careful review of the literature led to the following choices: 1) selection of Parkinsonian patients with dominant L-Dopa induced dyskinesia, akinetic and rigidity symptoms, 2) use of CT due to the distortion effects of MRI, 3) use of standard (Laitinen) coordinates combined with an image fusion method using MRI, 4) use of stimulation to gauge distance to internal capsule and optic tract, 5) production of vertical lesion covering internal segment of pallidum. At a 1-year follow-up the results include a 45% drop in UPDRS (Unified Parkinson's Disease Rating Scale) motor score and almost complete resolution of contralateral dopa induced dyskinesias in both patients.
Lingua originaleEnglish
pagine (da-a)105-115
Numero di pagine11
RivistaFunctional Neurology
Volume13
Stato di pubblicazionePublished - 1998

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Clinical Neurology

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    Iacopino, D., Lo Presti, R., Iacopino, D. G., Lucerna, S., Di Bella, P., Sessa, E., Salpietro, F. M., Bramanti, P., Tomasello, F., & Giller, C. A. (1998). Pallidotomy improves quality of life in selected parkinsonian patients: an Italian report. Functional Neurology, 13, 105-115.