Paediatric oral formulations: comparison of twoextemporaneously compounded suspensions fromtacrolimus capsules

Vita Di Stefano, Silvia Miriam Cammarata

Risultato della ricerca: Articlepeer review

Abstract

Study objectives: The objective of this study was to determine the stability of tacrolimus in extemporaneously compounded liquidformulations.Methods: Two sets of liquid formulations were prepared using two different vehicles: one set in sterile water and in simple syrup (1:1)and one set using equal volumes of commercially available suspending agent (Ora-Plus) and simple syrup. The concentration of tacrolimusin each formulation was 0.5 mg/mL. The preparations containing Ora-Plus were stored at 25°C, the formulations that wereprepared with sterile water and simple syrup were stored under refrigeration at 4°C.Results: Samples were collected at regular time intervals over a period of 56 days and tacrolimus concentration was determined usinga stability-indicating, high performance liquid chromatography (HPLC) assay. The concentration of drug was found to be within theacceptable limit (± 10%) of the initial concentration in all tested samples.Conclusion: The HPLC results showed that simple syrup/sterile water formulations stored at 4°C are stable for at least eight weeks
Lingua originaleEnglish
pagine (da-a)70-72
Numero di pagine3
RivistaEJHP Practice
Volume17
Stato di pubblicazionePublished - 2011

All Science Journal Classification (ASJC) codes

  • Pharmacology, Toxicology and Pharmaceutics(all)

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