Oxidative stress markers at birth: Analyses of a neonatal population

Francesco Cappello, Antonella Marino Gammazza, Giovanni Corsello, Mario Giuffre, Manfredi Rizzo, Alessandro Pitruzzella, Antonella Marino Gammazza, Alessandro Pitruzzella, Manfredi Rizzo, Giovanni Li Volti, Francesco Cappello, Giusi Maria Scaturro

Risultato della ricerca: Article

10 Citazioni (Scopus)

Abstract

In order to further understand neonatal stress and, thus, control it efficaciously, there is a need for more information on the manifestations of stress at the molecular level in the newborn, with particular regard to oxidants, and anti-oxidant and anti-stress mechanisms, including mitochondrial heat shock protein-chaperones such as Hsp60. We investigated patterns of anti-oxidants, biomarkers of oxidative stress, and Hsp60 levels in sera from newborns and found significant associations between glutathione (GSH) levels and gestational age, delivery modality, and lipid hydroperoxydes (LOOH) level. LOOH levels and spontaneous (vaginal) delivery were independently associated with increased GSH levels when these were above the median. Hsp60 and LOOH levels were positively correlated whereas Hsp60 and GSH levels were inversely correlated in spontaneously delivered newborns; in contrast, Hsp60 and GSH levels were positively correlated in newborns delivered by cesarea. Our results point to new directions in the search for definite patterns of GSH, LOOH, and Hsp60 in the newborn's serum that might have functional and diagnostic significance and that could help in the monitoring of newborn health during and after delivery. In addition, the data provide a starting basis for investigating the precise roles and interplay of GSH and Hsp60 in the maintenance of an optimal redox balance at birth to cope with the stress inherent to delivery, and also for investigating the predictive value of any given pattern of GSH, LOOH, and Hsp60 at birth with regard to health status and risk of disease in adult life.
Lingua originaleEnglish
Numero di pagine6
RivistaActa Histochemica
Stato di pubblicazionePublished - 2015

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Oxidants
Oxidative Stress
Parturition
Population
Mitochondrial Proteins
Heat-Shock Proteins
Serum
Health Status
Gestational Age
Oxidation-Reduction
Glutathione
Biomarkers
Maintenance
Lipids

All Science Journal Classification (ASJC) codes

  • Histology
  • Cell Biology

Cita questo

Oxidative stress markers at birth: Analyses of a neonatal population. / Cappello, Francesco; Marino Gammazza, Antonella; Corsello, Giovanni; Giuffre, Mario; Rizzo, Manfredi; Pitruzzella, Alessandro; Gammazza, Antonella Marino; Pitruzzella, Alessandro; Rizzo, Manfredi; Li Volti, Giovanni; Cappello, Francesco; Scaturro, Giusi Maria.

In: Acta Histochemica, 2015.

Risultato della ricerca: Article

Cappello, Francesco ; Marino Gammazza, Antonella ; Corsello, Giovanni ; Giuffre, Mario ; Rizzo, Manfredi ; Pitruzzella, Alessandro ; Gammazza, Antonella Marino ; Pitruzzella, Alessandro ; Rizzo, Manfredi ; Li Volti, Giovanni ; Cappello, Francesco ; Scaturro, Giusi Maria. / Oxidative stress markers at birth: Analyses of a neonatal population. In: Acta Histochemica. 2015.
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AU - Cappello, Francesco

AU - Marino Gammazza, Antonella

AU - Corsello, Giovanni

AU - Giuffre, Mario

AU - Rizzo, Manfredi

AU - Pitruzzella, Alessandro

AU - Gammazza, Antonella Marino

AU - Pitruzzella, Alessandro

AU - Rizzo, Manfredi

AU - Li Volti, Giovanni

AU - Cappello, Francesco

AU - Scaturro, Giusi Maria

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N2 - In order to further understand neonatal stress and, thus, control it efficaciously, there is a need for more information on the manifestations of stress at the molecular level in the newborn, with particular regard to oxidants, and anti-oxidant and anti-stress mechanisms, including mitochondrial heat shock protein-chaperones such as Hsp60. We investigated patterns of anti-oxidants, biomarkers of oxidative stress, and Hsp60 levels in sera from newborns and found significant associations between glutathione (GSH) levels and gestational age, delivery modality, and lipid hydroperoxydes (LOOH) level. LOOH levels and spontaneous (vaginal) delivery were independently associated with increased GSH levels when these were above the median. Hsp60 and LOOH levels were positively correlated whereas Hsp60 and GSH levels were inversely correlated in spontaneously delivered newborns; in contrast, Hsp60 and GSH levels were positively correlated in newborns delivered by cesarea. Our results point to new directions in the search for definite patterns of GSH, LOOH, and Hsp60 in the newborn's serum that might have functional and diagnostic significance and that could help in the monitoring of newborn health during and after delivery. In addition, the data provide a starting basis for investigating the precise roles and interplay of GSH and Hsp60 in the maintenance of an optimal redox balance at birth to cope with the stress inherent to delivery, and also for investigating the predictive value of any given pattern of GSH, LOOH, and Hsp60 at birth with regard to health status and risk of disease in adult life.

AB - In order to further understand neonatal stress and, thus, control it efficaciously, there is a need for more information on the manifestations of stress at the molecular level in the newborn, with particular regard to oxidants, and anti-oxidant and anti-stress mechanisms, including mitochondrial heat shock protein-chaperones such as Hsp60. We investigated patterns of anti-oxidants, biomarkers of oxidative stress, and Hsp60 levels in sera from newborns and found significant associations between glutathione (GSH) levels and gestational age, delivery modality, and lipid hydroperoxydes (LOOH) level. LOOH levels and spontaneous (vaginal) delivery were independently associated with increased GSH levels when these were above the median. Hsp60 and LOOH levels were positively correlated whereas Hsp60 and GSH levels were inversely correlated in spontaneously delivered newborns; in contrast, Hsp60 and GSH levels were positively correlated in newborns delivered by cesarea. Our results point to new directions in the search for definite patterns of GSH, LOOH, and Hsp60 in the newborn's serum that might have functional and diagnostic significance and that could help in the monitoring of newborn health during and after delivery. In addition, the data provide a starting basis for investigating the precise roles and interplay of GSH and Hsp60 in the maintenance of an optimal redox balance at birth to cope with the stress inherent to delivery, and also for investigating the predictive value of any given pattern of GSH, LOOH, and Hsp60 at birth with regard to health status and risk of disease in adult life.

KW - Anti-stress molecules

KW - Cell Biology

KW - Glutathione

KW - Histology

KW - Hsp60

KW - Lipid hydroperoxydes

KW - Neonatal stress

KW - Oxidative-stress markers

UR - http://hdl.handle.net/10447/124176

UR - http://www.urbanfischer.de/journals/actahist/acthist.htm

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