TY - JOUR
T1 - Oxidative stress, inflammation and cardiovascular disease in chronic renal failure
AU - Riccobene, Raffaella
AU - Geraci, Calogero
AU - Buscemi, Silvio
AU - Nardi, Emilio
AU - Cerasola, Giovanni
AU - Guarneri, Marco
AU - Cottone, Santina
AU - Mule', Giuseppe
AU - Cottone, Santina
AU - Lorito, Maria Carmela
AU - Arsena, Rosalia
PY - 2008
Y1 - 2008
N2 - Traditional risk factors such as hypertension, diabetes, dyslipidemia, obesity and metabolic syndrome, as well as additional nontraditional risk factors, can damage the kidney directly and by promoting intrarenal atherogenesis. Evidence indicates that increased oxidative stress and inflammation may mediate most of the effects of risk factors on the kidney. Clinical studies have demonstrated a relationship between oxidative stress and inflammatory biomarkers, and a few studies indicate an inverse correlation of oxidative stress biomarkers with estimated glomerular filtration rate (eGFR). Further, surrogate indexes of atherosclerosis such as intima-media thickness and aortic pulse wave velocity have been demonstrated to be related to plasma concentrations of markers of endothelial activation, inflammation and fibrosis in patients with different stages of chronic kidney disease (CKD). Moreover, plasma concentrations of high-sensitivity C-reactive protein have been shown to be increased and related to left ventricular mass in CKD individuals having left ventricular hypertrophy. In contrast, in these patients, decreases in fetuin-A plasma levels have been reported. Considering the complex background of the pathophysiological changes characterizing CKD patients, we can consider cardiovascular disease a multifactorial complication of CKD.
AB - Traditional risk factors such as hypertension, diabetes, dyslipidemia, obesity and metabolic syndrome, as well as additional nontraditional risk factors, can damage the kidney directly and by promoting intrarenal atherogenesis. Evidence indicates that increased oxidative stress and inflammation may mediate most of the effects of risk factors on the kidney. Clinical studies have demonstrated a relationship between oxidative stress and inflammatory biomarkers, and a few studies indicate an inverse correlation of oxidative stress biomarkers with estimated glomerular filtration rate (eGFR). Further, surrogate indexes of atherosclerosis such as intima-media thickness and aortic pulse wave velocity have been demonstrated to be related to plasma concentrations of markers of endothelial activation, inflammation and fibrosis in patients with different stages of chronic kidney disease (CKD). Moreover, plasma concentrations of high-sensitivity C-reactive protein have been shown to be increased and related to left ventricular mass in CKD individuals having left ventricular hypertrophy. In contrast, in these patients, decreases in fetuin-A plasma levels have been reported. Considering the complex background of the pathophysiological changes characterizing CKD patients, we can consider cardiovascular disease a multifactorial complication of CKD.
KW - C-Reactive Protein
KW - Pulse Wave Velocity
KW - chronic kidney disease; Isoprostanes
KW - C-Reactive Protein
KW - Pulse Wave Velocity
KW - chronic kidney disease; Isoprostanes
UR - http://hdl.handle.net/10447/55563
M3 - Article
VL - 21 (2)
SP - 175
EP - 179
JO - Journal of Nephrology
JF - Journal of Nephrology
SN - 1121-8428
ER -