Oxidative stress in young subjects with acute myocardial infarction. Evaluation at the initial stage and after 12 months.

Risultato della ricerca: Article

17 Citazioni (Scopus)

Abstract

In 105 subjects (97 men and 8 women) aged <46 years (mean age 39.6 +/- 5.5 years), with recent acute myocardial infarction (T1), thiobarbituric acid reactive substances and total antioxidant status were determined; NO production was evaluated by measuring the nitrite and nitrate (NOx) concentration. The patients with acute myocardial infarction were subdivided according to the main risk factors, number of risk factors, and extent of coronary lesions. The evaluation was repeated after 12 months (T2). In these subjects, thiobarbituric acid reactive substances and NOx were significantly increased and total antioxidant status was significantly decreased at T1. In single risk factor, only NO metabolites were significantly lower in acute myocardial infarction subjects who smoke than in subjects who do not. Subdividing the subjects according to the number of risk factors and number of stenosed coronary vessels, there were no significant differences between the subgroups. At T2, thiobarbituric acid reactive substances and NOx were decreased and total antioxidant status was increased, but all parameters were still altered.
Lingua originaleEnglish
pagine (da-a)421-427
Numero di pagine7
RivistaCLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
Volume14
Stato di pubblicazionePublished - 2008

Fingerprint

Thiobarbituric Acid Reactive Substances
Oxidative Stress
Myocardial Infarction
Antioxidants
Nitrites
Smoke
Nitrates
Coronary Vessels

All Science Journal Classification (ASJC) codes

  • Hematology

Cita questo

@article{025bb16da622495e933ac67ab19fe8a2,
title = "Oxidative stress in young subjects with acute myocardial infarction. Evaluation at the initial stage and after 12 months.",
abstract = "In 105 subjects (97 men and 8 women) aged <46 years (mean age 39.6 +/- 5.5 years), with recent acute myocardial infarction (T1), thiobarbituric acid reactive substances and total antioxidant status were determined; NO production was evaluated by measuring the nitrite and nitrate (NOx) concentration. The patients with acute myocardial infarction were subdivided according to the main risk factors, number of risk factors, and extent of coronary lesions. The evaluation was repeated after 12 months (T2). In these subjects, thiobarbituric acid reactive substances and NOx were significantly increased and total antioxidant status was significantly decreased at T1. In single risk factor, only NO metabolites were significantly lower in acute myocardial infarction subjects who smoke than in subjects who do not. Subdividing the subjects according to the number of risk factors and number of stenosed coronary vessels, there were no significant differences between the subgroups. At T2, thiobarbituric acid reactive substances and NOx were decreased and total antioxidant status was increased, but all parameters were still altered.",
keywords = "acute myocardial infarction in young people, lipid peroxidation, nitric oxide, oxidative status",
author = "Anna Catania and {Lo Presti}, Rosalia and Enrico Hoffmann and Gregorio Caimi",
year = "2008",
language = "English",
volume = "14",
pages = "421--427",
journal = "Clinical and Applied Thrombosis/Hemostasis",
issn = "1076-0296",
publisher = "SAGE Publications Inc.",

}

TY - JOUR

T1 - Oxidative stress in young subjects with acute myocardial infarction. Evaluation at the initial stage and after 12 months.

AU - Catania, Anna

AU - Lo Presti, Rosalia

AU - Hoffmann, Enrico

AU - Caimi, Gregorio

PY - 2008

Y1 - 2008

N2 - In 105 subjects (97 men and 8 women) aged <46 years (mean age 39.6 +/- 5.5 years), with recent acute myocardial infarction (T1), thiobarbituric acid reactive substances and total antioxidant status were determined; NO production was evaluated by measuring the nitrite and nitrate (NOx) concentration. The patients with acute myocardial infarction were subdivided according to the main risk factors, number of risk factors, and extent of coronary lesions. The evaluation was repeated after 12 months (T2). In these subjects, thiobarbituric acid reactive substances and NOx were significantly increased and total antioxidant status was significantly decreased at T1. In single risk factor, only NO metabolites were significantly lower in acute myocardial infarction subjects who smoke than in subjects who do not. Subdividing the subjects according to the number of risk factors and number of stenosed coronary vessels, there were no significant differences between the subgroups. At T2, thiobarbituric acid reactive substances and NOx were decreased and total antioxidant status was increased, but all parameters were still altered.

AB - In 105 subjects (97 men and 8 women) aged <46 years (mean age 39.6 +/- 5.5 years), with recent acute myocardial infarction (T1), thiobarbituric acid reactive substances and total antioxidant status were determined; NO production was evaluated by measuring the nitrite and nitrate (NOx) concentration. The patients with acute myocardial infarction were subdivided according to the main risk factors, number of risk factors, and extent of coronary lesions. The evaluation was repeated after 12 months (T2). In these subjects, thiobarbituric acid reactive substances and NOx were significantly increased and total antioxidant status was significantly decreased at T1. In single risk factor, only NO metabolites were significantly lower in acute myocardial infarction subjects who smoke than in subjects who do not. Subdividing the subjects according to the number of risk factors and number of stenosed coronary vessels, there were no significant differences between the subgroups. At T2, thiobarbituric acid reactive substances and NOx were decreased and total antioxidant status was increased, but all parameters were still altered.

KW - acute myocardial infarction in young people

KW - lipid peroxidation

KW - nitric oxide

KW - oxidative status

UR - http://hdl.handle.net/10447/39777

M3 - Article

VL - 14

SP - 421

EP - 427

JO - Clinical and Applied Thrombosis/Hemostasis

JF - Clinical and Applied Thrombosis/Hemostasis

SN - 1076-0296

ER -