Osteoporosis and bisphosphonates-related osteonecrosis of the jaw: Not just a sporadic coincidence-a multi-centre study

Giuseppina Campisi, Florian Haasters, Olivier Lieger, Mario Hakim Abu-Id, Elias Volkmer, Andreas Kolk, Thomas Mücke, Sven Otto, Patrick H. Warnke, Giuseppe Colella, Michael Ehrenfeld, Thomas Kreusch, Stephen R. Stürzenbaum, Oliver Ploder, Gerson Mast, Stefano Fedele, Jörg Wiltfang, Andreas Neff, Klaus-Dietrich Wolff, Stephen PorterTateyuki Iizuka, Robert Köhnke, Stephan T. Becker, Matthias Schieker, Christoph Pautke

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Abstract

Introduction: Bisphosphonates (BPs) are powerful drugs that inhibit bone metabolism. Adverse side effectsare rare but potentially severe such as bisphosphonate-related osteonecrosis of the jaw (BRONJ). To date,research has primarily focused on the development and progression of BRONJ in cancer patients with bonemetastasis, who have received high dosages of BPs intravenously. However, a potential dilemma may arisefrom a far larger cohort, namely the millions of osteoporosis patients on long-term oral BP therapy.Patients and methods: This current study assessed 470 cases of BRONJ diagnosed between 2004 and 2008at eleven different European clinical centres and has resulted in the identification of a considerablecohort of osteoporosis patients suffering from BRONJ. Each patient was clinically examined and a detailedmedical history was raised.Results: In total, 37/470 cases (7.8%) were associated with oral BP therapy due to osteoporosis. Themajority (57%) of affected individuals did not have any risk factors for BRONJ as defined by the AmericanAssociation of Oral and Maxillofacial Surgery. The average duration of BP intake of patients without riskfactors was longer and the respective patients were older compared to patients with risk factors, but nostatistical significant difference was found. In 78% of patients the duration of oral BP therapy exceeded 3years prior to BRONJ diagnosis.
Lingua originaleEnglish
pagine (da-a)272-277
Numero di pagine6
RivistaJOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
Volume39
Stato di pubblicazionePublished - 2011

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All Science Journal Classification (ASJC) codes

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology

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Campisi, G., Haasters, F., Lieger, O., Abu-Id, M. H., Volkmer, E., Kolk, A., Mücke, T., Otto, S., Warnke, P. H., Colella, G., Ehrenfeld, M., Kreusch, T., Stürzenbaum, S. R., Ploder, O., Mast, G., Fedele, S., Wiltfang, J., Neff, A., Wolff, K-D., ... Pautke, C. (2011). Osteoporosis and bisphosphonates-related osteonecrosis of the jaw: Not just a sporadic coincidence-a multi-centre study. JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY, 39, 272-277.