Osteonecrosis detected by whole body magnetic resonance in patients with Hodgkin Lymphoma treated by BEACOPP

Massimo Midiri, Ludovico La Grutta, Giuseppe Brancatelli, Massimo Galia, Roberto Lagalla, Domenico Albano, Caterina Patti, Antonino Mulè, Emanuele Grassedonio

Risultato della ricerca: Articlepeer review

17 Citazioni (Scopus)

Abstract

Objectives: The purpose of our retrospective review of prospectively acquired Whole Body Magnetic Resonance (WB-MRI) scans was to assess the incidence of osteonecrosis in patients who received different chemotherapies. Methods: We evaluated the WB-MRI scans performed on 42 patients with Hodgkin Lymphoma treated by three chemotherapy regimens (6ABVD, 2ABVD + 4BEACOPP, 2ABVD + 8BEACOPP), excluding patients with the main risk factors for osteonecrosis. Results: Six out of seven patients (86 %) who received eight BEACOPP and one out of five patients (20 %) treated by four BEACOPP presented osteonecrosis, with a statistically significant difference of frequency between the two groups of patients (p < 0.05); no injury has been reported in patients treated by only ABVD. Among a total of 48 osteonecrotic lesions observed, 48 % were detected in the knee; multifocal osteonecrosis were detected in six out of seven patients (86 %). Conclusions: The development of osteonecrosis is strictly related to the chemotherapy protocol adopted and the number of cycles received, with a strong correlation between the dose of corticosteroids included in the BEACOPP scheme and this complication. WB-MRI can be considered as a helpful tool that allows detecting earlier osteonecrotic lesions in patients treated with corticosteroids. Key Points: • Osteonecrosis is a possible complication of patients with Lymphoma treated by chemotherapy.• Osteonecrosis is related to the corticosteroids included within the BEACOPP protocol.• WB-MRI allows detecting osteonecrotic lesions in patients treated with corticosteroids.
Lingua originaleEnglish
pagine (da-a)2129-2136
Numero di pagine8
RivistaEuropean Radiology
Volume27
Stato di pubblicazionePublished - 2017

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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