Orexin system: Network multi-tasking

Gabriele Tripi, Lucia Parisi, Margherita Salerno, Agata Maltese, Michele Roccella, Giovanni Messina, Pasquale Cozzolino, Maria Ruberto, Gabriella Marsala, Antonietta Messina, Vincenzo Monda, Fiorenzo Moscatelli, Anna Valenzano, Ines Villano, Monica Salerno, Francesco Sessa, Palmira Romano, Emanuele Monda, Francesco Cerroni, Mauro N. MaldonatoRaffaele Sperandeo, Giuseppe Cibelli, Sergio Chieffi, Marcellino Monda, Rosa Marotta, Rosanna Marotta

Risultato della ricerca: Articlepeer review

26 Citazioni (Scopus)


Orexin system regulates sleep/wake states and its deficiency result in narcolepsy thus indicating the crucial role of orexins in maintaining wakefulness. There are two types of orexin peptides: the orexin-A (OXA or hypocretin 1) and orexin-B (OXB or hypocretin 2). The Majority of the central nervous system orexin peptides are synthesized in neurons located in the lateral and back hypothalamus and send projections throughout the brain regions Orexin neurons are "multi-tasking" hence regulating also energy homeostasis, reward systems and feeding behaviour through connection with hypothalamic nuclei and through responsiveness to leptine and glucose. It has recently been found a connection with lymbic system suggesting a further possible role of orexins in regulating emotions. All the studies conducted confirm that orexin system regulates vigilance states, energy homeostasis, reward system, and emotions. These crucial role might be the target to develope treatments of narcolepsy, obesity, emotional stress, and drug addiction.
Lingua originaleEnglish
pagine (da-a)349-356
Numero di pagine8
RivistaActa Medica Mediterranea
Stato di pubblicazionePublished - 2018

All Science Journal Classification (ASJC) codes

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