Magnesium (Mg) ions directly influence vascular tone and responsivenessand are cofactors for acetylcholine-induced endothelium-dependent relaxation.Alterations in extracellular Mg are able to modify the formation and releaseof nitric oxide (NO), altering arterial smooth muscle tone. Previous in vivostudies in humans have shown that parenteral or oral Mg supplementationincrease endothelial-dependent vasodilation. The aim of the present study was toevaluate the effects of Mg oral supplementation on endothelial function in elderlydiabetic and hypertensive subjects. Sixty elderly (≥ 65 years) diabetic patientswere recruited (mean age: 71.1 ± 6.1 years; M/F: 35/25). Endothelial function,evaluated by non-invasive flow-mediated dilatation of the brachial artery, as wellas anthropometric and laboratory data, including ionized Mg (Mg-ion), were measuredin all patients before and after one-month. Thirty patients underwent oralMg supplementation with 4.5 g/day of Mg pidolate (368 mg/day of Mg ion), whilethe rest were used as a control group. The usual management of diabetes andhypertension was not changed during the month of study participation for all thepatients. In the group of patients that underwent Mg supplementation, Mg-ion concentrationsignificantly increased from 0.42 ± 0.05 mmol/L to 0.49 ± 0.06 mmol/L;p < 0.05. Mg intervention resulted in a significant improvement of the postischemicendothelial-dependent flow-mediated dilation (from 3.3 ± 3.6% to8.4 ± 3.9%; p < 0.05). No significant differences were found, either in ion-Mg orendothelial function, in the control group. In conclusion, the present studysuggests that oral Mg improves endothelial function in diabetic elderly subjects.
|Numero di pagine||7|
|Stato di pubblicazione||Published - 2010|
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Clinical Biochemistry