Oral local drug delivery and new perspectives in oral drug formulation

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55 Citazioni (Scopus)


Modern pharmaceutical science has provided us with a wide range of substances to be administered with a widelarge variety of dosage forms. Local drug delivery systems have been used for a long time; in particular, for the local therapyof diseases affecting the oral cavity. Although these diseases are often extremely responsive to local therapy, the mouth oftenpresents various difficulties in the application of topical compounds (owing to saliva and the mouth’s different functions),resulting in a short retention time of dosage forms with a consequent low therapeutic efficacy. To resolve these limitations,research today concentrates on the development of bioadhesive formulations. This review focuses on the permeabilityfeatures of oral mucosa, the rationale of oral local drug delivery, and new potential bioadhesive local delivery systems.Furthermore, the most promising mucoadhesive systems proposed to locally treat oral diseases are discussed.
Lingua originaleEnglish
pagine (da-a)e25-e34
Numero di pagine10
RivistaOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Stato di pubblicazionePublished - 2012

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.3500.3504???
  • ???subjectarea.asjc.2700.2734???
  • ???subjectarea.asjc.3500.3501???
  • ???subjectarea.asjc.2700.2741???


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