Opposite role of pro-inflammatory alleles in acute myocardial infarction and longevity: results of studies performed in a Sicilian population

Gregorio Caimi, Carmela Rita Balistreri, Sonya Vasto, Domenico Lio, Calogero Caruso, Enrico Hoffmann, Giuseppina Candore, Giuseppina Colonna Romano, Claudio Franceschi, Giuseppe Paolisso, Calogero Caruso, Florinda Listi', Maria Paola Grimaldi

Risultato della ricerca: Articlepeer review

29 Citazioni (Scopus)

Abstract

The major trait characterizing offspring in centenarians is a reduction in the prevalence of cardiovascular disease. Because a pro-inflammatory genotype seems to contribute significantly to the risk of coronary heart disease, alleles associated with disease susceptibility would not be included in the genetic background favoring longevity, as suggested by our previous studies on inflammatory cytokines. To confirm whether genotypes of inflammatory molecules play an opposite role in atherosclerosis and longevity, we are studying the role of other proinflammatory alleles, such as pyrin and CCR5, in acute myocardial infarction and longevity. The results support the hypothesis that the genetic background favoring cardiovascular diseases is detrimental to longevity. In addition, they suggest that the centenarian genetic background may be useful for investigating genetic key components of age-associated diseases that are characterized by a multifactorial etiology
Lingua originaleEnglish
pagine (da-a)270-275
Numero di pagine6
RivistaAnnals of the New York Academy of Sciences
Volume1067
Stato di pubblicazionePublished - 2006

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.1300.1300???
  • History and Philosophy of Science

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