Opposite role of pro-inflammatory alleles in acute myocardial infarction and longevity: results of studies performed in a Sicilian population

Gregorio Caimi; Carmela Rita Balistreri; Sonya Vasto; Domenico Lio; Calogero Caruso; Enrico Hoffmann; Giuseppina Candore; Giuseppina Colonna Romano; Claudio Franceschi; Giuseppe Paolisso; Calogero Caruso; Florinda Listi'; Maria Paola Grimaldi

Opposite role of pro-inflammatory alleles in acute myocardial infarction and longevity: results of studies performed in a Sicilian population

Gregorio Caimi, Carmela Rita Balistreri, Sonya Vasto, Domenico Lio, Calogero Caruso, Enrico Hoffmann, Giuseppina Candore, Giuseppina Colonna Romano, Claudio Franceschi, Giuseppe Paolisso, Calogero Caruso, Florinda Listi', Maria Paola Grimaldi

Risultato della ricerca: Article › peer review

29 Citazioni (Scopus)

Abstract

The major trait characterizing offspring in centenarians is a reduction in the prevalence of cardiovascular disease. Because a pro-inflammatory genotype seems to contribute significantly to the risk of coronary heart disease, alleles associated with disease susceptibility would not be included in the genetic background favoring longevity, as suggested by our previous studies on inflammatory cytokines. To confirm whether genotypes of inflammatory molecules play an opposite role in atherosclerosis and longevity, we are studying the role of other proinflammatory alleles, such as pyrin and CCR5, in acute myocardial infarction and longevity. The results support the hypothesis that the genetic background favoring cardiovascular diseases is detrimental to longevity. In addition, they suggest that the centenarian genetic background may be useful for investigating genetic key components of age-associated diseases that are characterized by a multifactorial etiology

Lingua originale	English
pagine (da-a)	270-275
Numero di pagine	6
Rivista	Annals of the New York Academy of Sciences
Volume	1067
Stato di pubblicazione	Published - 2006

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History and Philosophy of Science

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Caimi, G., Balistreri, C. R., Vasto, S., Lio, D., Caruso, C., Hoffmann, E., Candore, G., Colonna Romano, G., Franceschi, C., Paolisso, G., Caruso, C., Listi', F., & Grimaldi, M. P. (2006). Opposite role of pro-inflammatory alleles in acute myocardial infarction and longevity: results of studies performed in a Sicilian population. Annals of the New York Academy of Sciences, 1067, 270-275.

Opposite role of pro-inflammatory alleles in acute myocardial infarction and longevity: results of studies performed in a Sicilian population. / Caimi, Gregorio ; Balistreri, Carmela Rita ; Vasto, Sonya ; Lio, Domenico ; Caruso, Calogero ; Hoffmann, Enrico ; Candore, Giuseppina ; Colonna Romano, Giuseppina; Franceschi, Claudio; Paolisso, Giuseppe; Caruso, Calogero; Listi', Florinda; Grimaldi, Maria Paola.

In: Annals of the New York Academy of Sciences, Vol. 1067, 2006, pag. 270-275.

Risultato della ricerca: Article › peer review

Caimi, G , Balistreri, CR , Vasto, S , Lio, D , Caruso, C , Hoffmann, E , Candore, G , Colonna Romano, G, Franceschi, C, Paolisso, G, Caruso, C, Listi', F & Grimaldi, MP 2006, 'Opposite role of pro-inflammatory alleles in acute myocardial infarction and longevity: results of studies performed in a Sicilian population', Annals of the New York Academy of Sciences, vol. 1067, pagg. 270-275.

Caimi, Gregorio ; Balistreri, Carmela Rita ; Vasto, Sonya ; Lio, Domenico ; Caruso, Calogero ; Hoffmann, Enrico ; Candore, Giuseppina ; Colonna Romano, Giuseppina ; Franceschi, Claudio ; Paolisso, Giuseppe ; Caruso, Calogero ; Listi', Florinda ; Grimaldi, Maria Paola. / Opposite role of pro-inflammatory alleles in acute myocardial infarction and longevity: results of studies performed in a Sicilian population. In: Annals of the New York Academy of Sciences. 2006 ; Vol. 1067. pagg. 270-275.

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title = "Opposite role of pro-inflammatory alleles in acute myocardial infarction and longevity: results of studies performed in a Sicilian population",

abstract = "The major trait characterizing offspring in centenarians is a reduction in the prevalence of cardiovascular disease. Because a pro-inflammatory genotype seems to contribute significantly to the risk of coronary heart disease, alleles associated with disease susceptibility would not be included in the genetic background favoring longevity, as suggested by our previous studies on inflammatory cytokines. To confirm whether genotypes of inflammatory molecules play an opposite role in atherosclerosis and longevity, we are studying the role of other proinflammatory alleles, such as pyrin and CCR5, in acute myocardial infarction and longevity. The results support the hypothesis that the genetic background favoring cardiovascular diseases is detrimental to longevity. In addition, they suggest that the centenarian genetic background may be useful for investigating genetic key components of age-associated diseases that are characterized by a multifactorial etiology",

author = "Gregorio Caimi and Balistreri, {Carmela Rita} and Sonya Vasto and Domenico Lio and Calogero Caruso and Enrico Hoffmann and Giuseppina Candore and {Colonna Romano}, Giuseppina and Claudio Franceschi and Giuseppe Paolisso and Calogero Caruso and Florinda Listi' and Grimaldi, {Maria Paola}",

year = "2006",

language = "English",

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journal = "Annals of the New York Academy of Sciences",

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T1 - Opposite role of pro-inflammatory alleles in acute myocardial infarction and longevity: results of studies performed in a Sicilian population

AU - Caimi, Gregorio

AU - Balistreri, Carmela Rita

AU - Vasto, Sonya

AU - Lio, Domenico

AU - Caruso, Calogero

AU - Hoffmann, Enrico

AU - Candore, Giuseppina

AU - Colonna Romano, Giuseppina

AU - Franceschi, Claudio

AU - Paolisso, Giuseppe

AU - Caruso, Calogero

AU - Listi', Florinda

AU - Grimaldi, Maria Paola

PY - 2006

Y1 - 2006

N2 - The major trait characterizing offspring in centenarians is a reduction in the prevalence of cardiovascular disease. Because a pro-inflammatory genotype seems to contribute significantly to the risk of coronary heart disease, alleles associated with disease susceptibility would not be included in the genetic background favoring longevity, as suggested by our previous studies on inflammatory cytokines. To confirm whether genotypes of inflammatory molecules play an opposite role in atherosclerosis and longevity, we are studying the role of other proinflammatory alleles, such as pyrin and CCR5, in acute myocardial infarction and longevity. The results support the hypothesis that the genetic background favoring cardiovascular diseases is detrimental to longevity. In addition, they suggest that the centenarian genetic background may be useful for investigating genetic key components of age-associated diseases that are characterized by a multifactorial etiology

AB - The major trait characterizing offspring in centenarians is a reduction in the prevalence of cardiovascular disease. Because a pro-inflammatory genotype seems to contribute significantly to the risk of coronary heart disease, alleles associated with disease susceptibility would not be included in the genetic background favoring longevity, as suggested by our previous studies on inflammatory cytokines. To confirm whether genotypes of inflammatory molecules play an opposite role in atherosclerosis and longevity, we are studying the role of other proinflammatory alleles, such as pyrin and CCR5, in acute myocardial infarction and longevity. The results support the hypothesis that the genetic background favoring cardiovascular diseases is detrimental to longevity. In addition, they suggest that the centenarian genetic background may be useful for investigating genetic key components of age-associated diseases that are characterized by a multifactorial etiology

UR - http://hdl.handle.net/10447/16291

M3 - Article

VL - 1067

SP - 270

EP - 275

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

SN - 0077-8923

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