[OP.4B.03] CIRCULATING ALDOSTERONE LEVELS ARE ASSOCIATED WITH CONCENTRIC LEFT VENTRICULAR GEOMETRY IN ESSENTIAL HYPERTENSIVE PATIENTS

Emilio Nardi, Laura Guarino, Giovanni Cerasola, Marco Guarneri, Santina Cottone, Giulio Geraci, Giuseppe Mule', Dario Altieri, Massimiliano Morreale, Valentina Cacciatore

Risultato della ricerca: Other

Abstract

OBJECTIVE: Sound evidence indicates that aldosterone has a fundamental role in determining functional and structural changes in the heart. Moreover, it has been observed that high plasma aldosterone concentration (PAC) is related to the development of congestive heart failure and to cardiovascular mortality. However, previous studies on the association between circulating aldosterone levels and left ventricular (LV) mass (LVM) and LV geometry, in subjects without primary aldosteronism yielded conflicting results. The aim of our study was to evaluate in patients with essential hypertension the relationships of PAC with LV mass and geometry, and to asses the influence of gender on these relationships.DESIGN AND METHOD: A total of 478 subjects (men: 63%; mean age 44 ± 12 years) with untreated essential hypertension were enrolled.The measurements included 24-h blood pressure (BP) readings, plasma renin activity (PRA) and PAC, obtained by radioimmunoassay and an echocardiogram.For its skewed distribution PAC was log transformed and expressed as median value and interquartile range.RESULTS: PAC was significantly lower (p < 0.01) in subjects with normal LVM indexed for body surface area (BSA) (n = 272) [7.5 (5.3-12.4)], as compared to those with concentric remodeling (n = 61) [10.2 [7.95-14.5)], to the patients with eccentric LV hypertrophy (LVH) (n = 90) [9.8 (6.9-12.9)], and to the subjects with concentric LVH (n = 61) [11.3 (7.7-16.6 ng/ml)]. Significant correlations of Log (PAC) with LVM, either indexed for BSA (r = 0.20; p < 0.0001), or for height 2.7 (r = 0.21; p < 0.0001) and with relative wall thickness (RWT) (r = 0.18; p < 0.0001) were found. These correlations were similar in men and in women and remained statistically significant in multiple regression analyses, even after adjustment for potential confounding factors (all p < 0.01).CONCLUSIONS: Our results seem to suggest that in essential hypertensive patients circulating aldosterone levels are independently associated with concentric LV geometry, without gender-related differences.
Lingua originaleEnglish
Paginee44-e44
Numero di pagine1
Stato di pubblicazionePublished - 2016

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Aldosterone
Body Surface Area
Hyperaldosteronism
Equidae
Left Ventricular Hypertrophy
Renin
Hypertrophy
Radioimmunoassay
Reading
Heart Failure
Regression Analysis
Blood Pressure
Mortality

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@conference{862ac5e3ed2148d0b77c13706736ad4e,
title = "[OP.4B.03] CIRCULATING ALDOSTERONE LEVELS ARE ASSOCIATED WITH CONCENTRIC LEFT VENTRICULAR GEOMETRY IN ESSENTIAL HYPERTENSIVE PATIENTS",
abstract = "OBJECTIVE: Sound evidence indicates that aldosterone has a fundamental role in determining functional and structural changes in the heart. Moreover, it has been observed that high plasma aldosterone concentration (PAC) is related to the development of congestive heart failure and to cardiovascular mortality. However, previous studies on the association between circulating aldosterone levels and left ventricular (LV) mass (LVM) and LV geometry, in subjects without primary aldosteronism yielded conflicting results. The aim of our study was to evaluate in patients with essential hypertension the relationships of PAC with LV mass and geometry, and to asses the influence of gender on these relationships.DESIGN AND METHOD: A total of 478 subjects (men: 63{\%}; mean age 44 ± 12 years) with untreated essential hypertension were enrolled.The measurements included 24-h blood pressure (BP) readings, plasma renin activity (PRA) and PAC, obtained by radioimmunoassay and an echocardiogram.For its skewed distribution PAC was log transformed and expressed as median value and interquartile range.RESULTS: PAC was significantly lower (p < 0.01) in subjects with normal LVM indexed for body surface area (BSA) (n = 272) [7.5 (5.3-12.4)], as compared to those with concentric remodeling (n = 61) [10.2 [7.95-14.5)], to the patients with eccentric LV hypertrophy (LVH) (n = 90) [9.8 (6.9-12.9)], and to the subjects with concentric LVH (n = 61) [11.3 (7.7-16.6 ng/ml)]. Significant correlations of Log (PAC) with LVM, either indexed for BSA (r = 0.20; p < 0.0001), or for height 2.7 (r = 0.21; p < 0.0001) and with relative wall thickness (RWT) (r = 0.18; p < 0.0001) were found. These correlations were similar in men and in women and remained statistically significant in multiple regression analyses, even after adjustment for potential confounding factors (all p < 0.01).CONCLUSIONS: Our results seem to suggest that in essential hypertensive patients circulating aldosterone levels are independently associated with concentric LV geometry, without gender-related differences.",
author = "Emilio Nardi and Laura Guarino and Giovanni Cerasola and Marco Guarneri and Santina Cottone and Giulio Geraci and Giuseppe Mule' and Dario Altieri and Massimiliano Morreale and Valentina Cacciatore",
year = "2016",
language = "English",
pages = "e44--e44",

}

TY - CONF

T1 - [OP.4B.03] CIRCULATING ALDOSTERONE LEVELS ARE ASSOCIATED WITH CONCENTRIC LEFT VENTRICULAR GEOMETRY IN ESSENTIAL HYPERTENSIVE PATIENTS

AU - Nardi, Emilio

AU - Guarino, Laura

AU - Cerasola, Giovanni

AU - Guarneri, Marco

AU - Cottone, Santina

AU - Geraci, Giulio

AU - Mule', Giuseppe

AU - Altieri, Dario

AU - Morreale, Massimiliano

AU - Cacciatore, Valentina

PY - 2016

Y1 - 2016

N2 - OBJECTIVE: Sound evidence indicates that aldosterone has a fundamental role in determining functional and structural changes in the heart. Moreover, it has been observed that high plasma aldosterone concentration (PAC) is related to the development of congestive heart failure and to cardiovascular mortality. However, previous studies on the association between circulating aldosterone levels and left ventricular (LV) mass (LVM) and LV geometry, in subjects without primary aldosteronism yielded conflicting results. The aim of our study was to evaluate in patients with essential hypertension the relationships of PAC with LV mass and geometry, and to asses the influence of gender on these relationships.DESIGN AND METHOD: A total of 478 subjects (men: 63%; mean age 44 ± 12 years) with untreated essential hypertension were enrolled.The measurements included 24-h blood pressure (BP) readings, plasma renin activity (PRA) and PAC, obtained by radioimmunoassay and an echocardiogram.For its skewed distribution PAC was log transformed and expressed as median value and interquartile range.RESULTS: PAC was significantly lower (p < 0.01) in subjects with normal LVM indexed for body surface area (BSA) (n = 272) [7.5 (5.3-12.4)], as compared to those with concentric remodeling (n = 61) [10.2 [7.95-14.5)], to the patients with eccentric LV hypertrophy (LVH) (n = 90) [9.8 (6.9-12.9)], and to the subjects with concentric LVH (n = 61) [11.3 (7.7-16.6 ng/ml)]. Significant correlations of Log (PAC) with LVM, either indexed for BSA (r = 0.20; p < 0.0001), or for height 2.7 (r = 0.21; p < 0.0001) and with relative wall thickness (RWT) (r = 0.18; p < 0.0001) were found. These correlations were similar in men and in women and remained statistically significant in multiple regression analyses, even after adjustment for potential confounding factors (all p < 0.01).CONCLUSIONS: Our results seem to suggest that in essential hypertensive patients circulating aldosterone levels are independently associated with concentric LV geometry, without gender-related differences.

AB - OBJECTIVE: Sound evidence indicates that aldosterone has a fundamental role in determining functional and structural changes in the heart. Moreover, it has been observed that high plasma aldosterone concentration (PAC) is related to the development of congestive heart failure and to cardiovascular mortality. However, previous studies on the association between circulating aldosterone levels and left ventricular (LV) mass (LVM) and LV geometry, in subjects without primary aldosteronism yielded conflicting results. The aim of our study was to evaluate in patients with essential hypertension the relationships of PAC with LV mass and geometry, and to asses the influence of gender on these relationships.DESIGN AND METHOD: A total of 478 subjects (men: 63%; mean age 44 ± 12 years) with untreated essential hypertension were enrolled.The measurements included 24-h blood pressure (BP) readings, plasma renin activity (PRA) and PAC, obtained by radioimmunoassay and an echocardiogram.For its skewed distribution PAC was log transformed and expressed as median value and interquartile range.RESULTS: PAC was significantly lower (p < 0.01) in subjects with normal LVM indexed for body surface area (BSA) (n = 272) [7.5 (5.3-12.4)], as compared to those with concentric remodeling (n = 61) [10.2 [7.95-14.5)], to the patients with eccentric LV hypertrophy (LVH) (n = 90) [9.8 (6.9-12.9)], and to the subjects with concentric LVH (n = 61) [11.3 (7.7-16.6 ng/ml)]. Significant correlations of Log (PAC) with LVM, either indexed for BSA (r = 0.20; p < 0.0001), or for height 2.7 (r = 0.21; p < 0.0001) and with relative wall thickness (RWT) (r = 0.18; p < 0.0001) were found. These correlations were similar in men and in women and remained statistically significant in multiple regression analyses, even after adjustment for potential confounding factors (all p < 0.01).CONCLUSIONS: Our results seem to suggest that in essential hypertensive patients circulating aldosterone levels are independently associated with concentric LV geometry, without gender-related differences.

UR - http://hdl.handle.net/10447/211238

UR - http://journals.lww.com/jhypertension/toc/2016/09002

M3 - Other

SP - e44-e44

ER -