The reaction of 5-polyfluoroaryl-1,2,4-oxadiazoles with methylhydrazine has been studied and the synthesis of fluorinated N-methylindazoles has been realized. Rearrangement reactions showed predominantlyformation of N(1)-methylindazole regioisomers. Starting compounds were preliminarily functionalized at the polyfluoroaryl moiety through fluorine displacement with nucleophiles (methanol,methylamine, dimethylamine), allowing the obtainment of target indazoles substituted at the C(6)position.
|Numero di pagine||9|
|Stato di pubblicazione||Published - 2009|
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry