On the origin of functionalization in one-pot radiation synthesis of nanogels from aqueous polymer solutions

Natascia Grimaldi, Clelia Dispenza, Maria Antonietta Sabatino, Marta Walo, Dispenza, Murugan, Maria Rosalia Mangione, Jonsson, Murugan

Risultato della ricerca: Articlepeer review

16 Citazioni (Scopus)

Abstract

Radiation-engineered poly(N-vinyl pyrrolidone) nanogels are very interesting biocompatible nanocarriers for i.v. administration of therapeutics and contrast agents for bioimaging. The manufacturing process is fast and effective, it grants excellent control of particle size and simultaneous sterilization of the formed nanogels. Interestingly, primary amino groups and carboxyl groups, useful for (bio)conjugation, are also formed in a dose-dependent fashion. In this paper, by means of both numerical simulations and experiments, the origin of nanogel size control and functionalization is investigated. This understanding offers a new dimension for the design and production of radiation-sculptured multifunctional nanocarriers from aqueous solutions of polymers.
Lingua originaleEnglish
pagine (da-a)2582-2591
Numero di pagine10
RivistaRSC Advances
Volume6
Stato di pubblicazionePublished - 2016

All Science Journal Classification (ASJC) codes

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  • ???subjectarea.asjc.1500.1500???

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