On the G‐quadruplex binding of a new class of Ni(II), Cu(II) and Zn(II) salphen‐like complexes

Alessio Terenzi, Gianluca Farine, Giampaolo Barone, Fabrizio Lo Celso, Riccardo Bonsignore, Antonio Santoro, Giuseppe Bruno, Riccardo Bonsignore, Giuseppe Bruno, Fabrizio Lo Celso

Risultato della ricerca: Articlepeer review

4 Citazioni (Scopus)

Abstract

The involvement of non-canonical DNA structures, such as Gquadruplex (G4) DNA, in cancer development and progression has set the pace towards the renaissance of DNA-binding metal complexes. In this work, we report the DNA-binding of three Ni(II), Cu(II), Zn(II) complexes of a salphen-like N4-donor ligand, bearing two imidazole groups condensed with a phenylenediamine moiety. Both duplex and G4 DNAs derived from human telomeres (hTelo), and a sequence mimicking the promoter of the oncogene myc (c-myc) were studied. UV-Vis and circular dichroism spectroscopic binding studies pointed out that, while all the three complexes bind the selected oligonucleotides, the Cu(II) derivative is the strongest and G4-selective compound of the series. Lastly, FRET DNA melting assay results on the Cu(II) complex/hTelo G4 system were interpreted by a loop-binding mechanism of interaction, as corroborated by molecular dynamics (MD) simulations.
Lingua originaleEnglish
pagine (da-a)1-6
Numero di pagine6
RivistaEUROPEAN JOURNAL OF INORGANIC CHEMISTRY
Stato di pubblicazionePublished - 2021

All Science Journal Classification (ASJC) codes

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